Instytut Chemii Bioorganicznej Pan

Beata Plitta

Marcin Krzysztof Chmielewski

Eliza Wyszko

Jan Barciszewski

Wojciech T Markiewicz

Ewelina Adamska

Maria Markiewicz

Agnieszka Fedoruk-Wyszomirska

Tadeusz Kulinski

Malgorzata Giel-Pietraszuk

A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula  where Ris H, R, R, 2'-deoxyribosyl, Ris alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then Ris no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then Rand Rare independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.

Cytosine analogue, a method of preparation of a cytosine analogue, a DNA methyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated with deviations from normal DNA methylation

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Poznan, Poland

Beata Plitta