Viiv Healthcare UK (no.5) Limited

Beata Nowicka-Sans

Nicholas A Meanwell

Sing-Yuen Sit

Yan Chen

Alicia Regueiro-Ren

Jie Chen

Ny Sin

Jacob Swidorski

Richard A Hartz

Brian Lee Venables

Ira B Dicker

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.

C-3 and C-17 modified triterpenoids as HIV-1 inhibitors

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I:  These compounds are useful for the treatment of HIV and AIDS.

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Wallingford, CT, United States of America

Beata Nowicka-Sans