Lonza Ag

Syntex (u.s.a.) Inc.

Syntex LLC

Beat Schmidt

Hans Maag

Samuel J Rose

Gerhard C Stucky

Andreas Kiener

John McGarrity

A process for the preparation of dihydroxypyrimidine derivatives of the general formula:

Method of producing dihydroxypyrimidine derivatives

Process for preparing substituted pyrimidine derivatives

This invention relates to use of oligonucleotides having at least one nucleotide that is substituted at the 4'-position of the sugar moiety with a substituent other than hydrogen as nucleotide probes in methods for detecting the presence or amount of a polynucleotide analyte in a sample suspected of containing the polynucleotide analyte. These oligonucleotides can also be packaged in diagnostic assay kits.

Methods of detecting nucleic acids with nucleotide probes containing

A novel process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol of the general formula: ##STR1## in which R is a C.sub.1 -C.sub.8 -alkyl group. In the process, cyanamide is reacted with the appropriate alcohol in the presence of hydrogen chloride to give the corresponding alkoxyisourea hydrochloride, which is then converted with ethyl trifluoroacetoacetate in the presence of an alkali metal hydroxide, which is in water, to the end product of the formula I.

Process for the preparation of a

This invention relates to oligonucleotides having at least one nucleotide that is substituted at the 4' position of the sugar moiety with a substituent other than hydrogen. These oligonucleotides are useful in hybridization assays and as therapeutic agents.

Growing community of inventors

Baltschieder, Switzerland

Beat Schmidt