Sabanci ÜNiversitesi

Koç Üniversitesi

Nova Southeastern University

Acibadem Mehmet Ali Aydinlar Üniversitesi

Batu Erman

Tolga Sutlu

Meltem Muftuoglu

Adil Doganay Duru

Burak Erman

Pol γ protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol γ. The compounds were shown to directly interact with Pol γ and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.

DNA polymerase gamma inhibitor and uses thereof

The invention provides modified Natural Killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex. These NK cells are used for T cell receptor (TCR) gene therapy in order to circumvent any risk of mispairing of the TCR a and &#x3b2; chains and to provide Major Histocompatibility Complex (MHC)-restricted antigen-specific cytotoxicity to the NK cells. The invention additionally provides methods for producing the modified NK cells, therapeutic compositions including the modified NK cells, and methods for using the modified NK cells in therapy of cancer, viral infections, autoimmunity, and graft versus host disease (GvHD).

Natural killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex, methods for production thereof, and methods for therapeutic use thereof

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Tuzla/Istanbul, Turkey

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