Microbiological Research Authority

Syntaxin Limited

Microbiobiological Research Authority

Bassam Hallis

Clifford Charles Shone

Conrad Padraig Quinn

Benjamin Arthur James

John Mark Sutton

Nigel Silman

Benjamin Arthur Frederick James

A composition for delivery of superoxide dismutase to neuronal cells comprise a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first domain that binds to a neuronal cell and a second domain that translocates the superoxide dimutase into the neuronal cell. After translocation, the linker is cleaved to release superoxide dimutase from the neuronal cell targeting domain. Also described is use of the composition for treatment of oxidative damage to neuronal cells and further targeting of the composition using human mitochondrial leader sequences. A hybrid polypeptide is described that contains a bacterial superoxide dismutase plus a sequence that targets a human mitochondira.

Delivery of superoxide dismutase to neuronal cells

A toxin assay that uses a substrate for cleavage by the toxin and antibodies that do not recognise the substrate but recognise and bind to the product of cleavage of the substrate by the toxin. The substrate can be a nerve cell peptide when the assay is for botulinum toxin or tetanus toxin.

Toxin Assay

A toxin assay that uses a substrate for cleavage by the toxin and antibodies that do not recognize the substrate but recognize and bind to the product of cleavage of the substrate by the toxin. The substrate can be a nerve cell peptide when the assay is for botulinum toxin or tetanus toxin.

Antibody for a toxin assay, and method of obtaining same

Toxin assay

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Salisbury, United Kingdom

Bassam Hallis