Nexmed (Holdings) Incorporated

Innovus Pharmaceuticals, Inc.

Angstrom Pharmaceuticals, Inc.

Pharmacopeia Inc.

Pharmacopeia Drug Discovery, Inc.

Bio-Quant, Inc.

Fastrack Pharmaceuticals, Inc.

Aytu Biopharma, Inc.

Bassam Damaj

Richard Martin

Daniel W Frank

James Inglese

Malcolm Finlayson

J Fraser Glickman

Jonathan J Burbaum

Maria Webb

Oral compositions comprising cinnamaldehyde, and methods or improving circulation and improving circulation by administering such compositions, are described. Methods and uses are describe that include the administration of an effective amount of the oral compositions to improve circulation and increasing nerve sensitization, while also resulting in improved balance, and reduced pain, numbness, and/or tingling in the hands and feet, as well as reduced restlessness, fatigue, and tiredness of the legs.

Oral compositions comprising cinnamaldehyde and uses thereof

Oral compositions for supporting bladder function, reduce frequency of urination, and/or improve or maintain bladder control, suitable for oral administration, are described. Methods of use and uses are described, which include the step of administering an effective amount of the oral compositions to supporting bladder function, reduce frequency of urination, and/or improve or maintain bladder control.

Oral compositions for bladder regulation and uses thereof

The invention provides unit dosage forms and methods that are effective to improve prostate function. Such unit dosage forms and methods are useful to decrease bladder discomfort and improve urinary flow in men.

Prostate function support formula

The invention provides compositions and methods that are effective to improve NO production in vivo and/or to increase NO levels in blood. Such compositions and methods may be useful to improve the effects of PDEinhibitors, for example, on erectile dysfunction or pulmonary hypertension.

Therapeutic methods and compositions

The invention provides compositions and methods that are effective to improve NO production in vivo and/or to increase NO levels in blood. Such compositions and methods are useful to improve sexual function in males and females.

Nutritional supplement for improving sexual health in men and women

The invention provides compositions and unit dosage forms that are effective to improve sexual performance. Such compositions and unit dosage forms are useful to increase duration of sexual intercourse, satisfaction with sexual intercourse, and improve erectile function in men.

Therapeutic compositions and methods

In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin Ecompound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.

Methods and compositions for treating Raynaud's disease

The invention provides compositions and methods that are effective to improve NO production in vivo and/or to increase NO levels in blood. Such compositions and methods are useful to increase oxygenation of the brain and to improve cognitive function.

Nutritional supplement for increasing cognitive functions

Methods and compositions for treating raynaud's disease

Compositions containing a small molecule therapeutic and an alkyl N,N-disubstituted amino acetate are disclosed. Inclusion of the alkyl N,N-disubstituted amino acetate enhances the pharmacokinetic properties of the small molecule therapeutic.

Compositions of small molecule therapeutics

In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.

The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.

Antimicrobial compounds and methods of use

A method of treating a disease characterized by aberrant cell migration and/or invasion includes administering to a subject an effective amount of the peptide of SEQ ID NO:3, an &#x212b;6 polypeptide, or an isolated polypeptide consisting essentially of the Link region of human CD44 as indicated in FIG.to modulate a FAK signal transduction pathway for a sufficient period of time to treat the disease. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes measuring the effect of these polypeptides on FAK signal transduction activity; wherein a change in FAK signal transduction activity is indicative of said aberrant cell migration or invasion. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes imaging FAK signal transduction activity in the presence of these polypeptides.

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San Diego, CA, United States of America

Bassam Damaj