Forge Therapeutics, Inc.

Louisiana State University and Agricultural & Mechanical College

University of Kansas

Oklahoma State University

Blacksmith Medicines, Inc.

Baskar Nammalwar

Min Teng

David Thomas Puerta

Konstantin Taganov

Xiaoming Li

Holly Atton

Krishna Kumar Gnanasekaran

Ian Yule

Serge Convers-Reignier

Richard A Bunce

Scott Lovell

Adele Faulkner

Christian Perez

Kate Eshelman

Michelle Southey

Alastair Parkes

Mario Rivera

Huili Yao

Anabel Soldano

Achala N D Punchi Hewage

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

Antibacterial compounds

The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I:

Use of small molecule inhibitors of the BfrB:Bfd interaction in biofilms

The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin.

Small molecule inhibitors of the BfrB:Bfd interaction

Provided herein is an LpxC inhibitor compound, as well as methods of making and pharmaceutical compositions comprising said compound, and methods of use thereof in the treatment of disease that would benefit from treatment with an LpxC inhibitor, including gram-negative bacterial infections such as urinary tract infections and the like.

LpxC inhibitor and methods of making

Provided herein are heterocyclic derivative compounds of Formula (II), and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like. 

The present teachings relate to hydroxypyrimidinone derivatives of Formula II, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections. 

Substituted pyrimidines for treating bacterial infections

The present teachings relate to pyrone derivatives, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections.

Pyrone based compounds for treating bacterial infections

The present teachings relate to hydroxypyrimidinone derivatives of Formula IV, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections. 

Substituted hydroxypyrimidinones for treating bacterial infections

Growing community of inventors

San Diego, CA, United States of America

Baskar Nammalwar