Duke University

Georgia Tech Research Corporation

Children's Healthcare of Atlanta, Inc.

Barun Brahma

Ravi Bellamkonda

Nassir Mokarram-Dorri

Jack C Griffis, Iii

James Leo Pokorney

Donald Kenneth Griffin, Ii

Anjana Jain

Ravi V Bellamkonda

An apparatus for guiding the migration of cancer and other cells includes a reservoir device, a cover, a tube, a nanofiber structure, and a lock device. The reservoir device defines a reservoir having an open top. The cover is configured for removable installation over the open top of the reservoir. The tube has a proximal end portion reaching into the reservoir. The nanofiber structure communicates an inlet port in the tube with the reservoir. The lock device interlocks the tube with the reservoir device, and also interlocks the nanofiber structure with the reservoir device.

Bi-directional access to tumors

Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.

Devices, systems, and methods for excavating cancer cells

Growing community of inventors

Atlanta, GA, United States of America

Barun Brahma