Lawrence Livermore National Security, LLC

Xenogen Corporation

Barton V Beeman

Peter A Krulevitch

William J Benett

M Allen Northrup

Bradley W Rice

Michael D Cable

Michael Bo Nelson

Dean R Hadley

Brian R Bates

Phoebe Landre

Stacy L Lehew

Brian Roberts Bates

A chemical reaction chamber system that combines devices such as doped polysilicon for heating, bulk silicon for convective cooling, and thermoelectric (TE) coolers to augment the heating and cooling rates of the reaction chamber or chambers. In addition the system includes non-silicon-based reaction chambers such as any high thermal conductivity material used in combination with a thermoelectric cooling mechanism (i.e., Peltier device). The heat contained in the thermally conductive part of the system can be used/reused to heat the device, thereby conserving energy and expediting the heating/cooling rates. The system combines a micromachined silicon reaction chamber, for example, with an additional module/device for augmented heating/cooling using the Peltier effect. This additional module is particularly useful in extreme environments (very hot or extremely cold) where augmented heating/cooling would be useful to speed up the thermal cycling rates. The chemical reaction chamber system has various applications for synthesis or processing of organic, inorganic, or biochemical reactions, including the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction.

Sleeve reaction chamber system

The invention describes systems and methods for calibrating a low-level light imaging system. Techniques described herein employ a light calibration device that is placed within a low level light imaging box to calibrate the system and its constituent components such as the camera and processing system. The calibration device comprises an array of low-power light supplies each having a known emission. By taking an image of each low-power light supply, and comparing the processed result with the known emission, the accuracy of the imaging system and its absolute imaging characteristics may be assessed and verified.

Light calibration device for use in low level light imaging systems

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San Mateo, CA, United States of America

Barton V Beeman