Nl Industries

Barton C Case

Thaddeus F Kroplinski

Melvin Brauer

Marvin T Tetenbaum

The present invention is directed to improved separatory devices employing polyurethane forming compositions, such as hollow fiber separatory devices intended to be used in biomedical applications. The separatory device employs at least one separatory membrane, suitable for the intended end use application, which is secured, potted or sealed in a housing using a cured polyurethane composition. The improvement comprises utilizing as the potting agent a polyurethane composition comprising the reaction product of an NCO-terminated prepolymer and a hydroxy terminated lactone derived polyester. The lactone polyester comprises the reaction product of a lactone such as caprolactone, and a polyol such as 1,6-hexane diol. The lactone derived polyester imparts to the polyurethane-forming composition a desirable balance of properties, including low mix viscosity, high reactivity, i.e., low gel and demold times, and acceptable hardness values, when used as a potting agent in biomedical separatory devices.

Biomedical devices

Novel thixotropic polyurethane compositions particularly useful as sealants for the edges of folded membrane separatory devices are provided which comprise;

Thixotropic polyurethane compositions as sealants for membrane

The present invention is directed to improvements in non-toxic polyurethane compositions and separatory devices employing the same, such as hollow fiber separatory devices intended to be used in biomedical applications. The separatory device employs at least one separatory membrane suitable for the intended end use application which is secured, potted or sealed in a housing using a cured flexible polyurethane composition. The improvement in the polyurethane composition employed in the separatory device is achieved by reacting at least one NCO-terminated prepolymer and at least one polyol in the presence of a ricinoleic acid reactive catalyst. The catalyst reduces the curing time of the polyurethane resin and because it is sufficiently reactive with the NCO-terminated prepolymer, it is incorporated into the structure of the polyurethane and cannot be released during operation of the separatory device.

Catalyzed non-toxic polyurethane forming compositions and separatory

A non-wicking polyurethane casting system has been developed which comprises the reaction product obtained by admixing a polyol containing N-N-N'-N'-tetrakis (2-hydroxypropyl) ethylene diamine, (hereafter referred to as QUADROL) with an isocyanate terminated polyurethane based prepolymer. This non-wicking casting system is useful as a potting compound in biomedical applications such as dialysis and hemoultrafiltration devices and the like.

Non-wicking polyurethane casting systems

A hollow fiber separatory device is provided wherein a polyurethane prepolymer is cross-linked or cured with an ester of a polyhydric alcohol which contains two or three hydroxyl groups, e.g., propylene glycol monoricinoleate, and an aliphatic acid of at least 12 carbon atoms and one or more epoxy and/or hydroxy groups per molecule.

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Howell, NJ, United States of America

Barton C Case