Universiteit Gent

Bart Verbraeken

Richard Hoogenboom

The invention relates to invention relates to a statistical copolymer represented by the following formula (I): Ini-[Ox]-[Oz]-Nuc (I) wherein: Ini represents a residue of an initiator of cationic polymerization, Nuc represents a residue of a nucleophilic agent, Ox represents N(R)CHRCHR; each Rindependently represents H or C(O)R; and Rindependently represents optionally substituted Calkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; Oz represents N(R)CHRCHRCHR; each Rindependently represents C(O)Ror H; and Rindependently represents optionally substituted Calkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; each Rindependently represents H, linear or branched Calkyl; m&#x2265;5; n&#x2265;5; m+n&#x2265;20; 3:97&#x2264;m:n&#x2264;97:3. The statistical copolymers of the present invention exhibit useful properties that can be exploited in the medical field, especially in polymer micelles for drug delivery and polyplexes for DNA delivery.

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Lummen, Belgium

Bart Verbraeken