Children's Medical Center Corporation

Celgene Corporation

Barry P Conner

Robert J D'Amato

Jamshed H Shah

Anthony Treston

Kimberly A Hunsucker

Glenn M Swartz

John Rougas

Victor Pribdula

Victor S Pribluda

Robert J D'amato

Victor Pribluda

The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(&#x2212;)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.

Synthesis of 4-amino-thalidomide enantiomers

Method of synthesis of 4-amino-thalidomide enantiomers

The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, nitrogen-substituted thalidomide analogs and di-substituted thalidomide analogs have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.

Use of nitrogen substituted thalidomide analogs for the treatment of macular degenerator

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Laurel, MD, United States of America

Barry P Conner