Heartware, Inc.

Microchips, Inc.

Advastim, Inc.

Peacs Investments B.v.

Christopher & Weisberg, P.a.

Kardionav, Inc.

Cardiac Pacemakers, Inc.

Drãgerwerk Ag & Co, Kgaa

Barry Mitchell Yomtov

John Robert Batty, Jr

Daniel Tamez

Stephen Jack Herman

Joseph M Bocek

Scott Albert Uhland

John T Santini, Jr

Norman F Sheppard, Jr

Fernando Casas

Benjamin F Polito

Robert Pacheco

Marvin L Sussman

John M Maloney

Tracy K Ginnings

Norman F Sheppard

Paul E De Coriolis

John Batty

Marvin Sussmann

John Robert Batty

A method of arrhythmia localization and model merging includes: generating a three-dimensional (3D) heart model of a heart of a patient, the 3D heart model including myocardium wall thickness measurements of the heart; generating an activation map of the heart based on electrocardiogram (ECG) data recorded during premature ventricular contraction (PVC) of the heart, the activation map including a PVC onset point; modifying the 3D heart model to include the PVC onset point; and displaying the modified 3D heart model on a display device.

Methods of ventricular arrhythmia localization using a 3D heart model

Various embodiments include methods of cardiac resynchronization therapy (CRT). Various embodiments may include: generating, using a processing unit, a cardiac activation map including a three-dimensional (3D) heart model of the heart that shows coronary vessels of a patient and shows the propagation of electrical signals through the 3D heart model; determining the location of a left bundle branch block (LBBB) based on the cardiac activation map; implanting a first pacing device and a second pacing device into the patient; stimulating the His Bundle of the heart using the first pacing device; and stimulating the left ventricle (LV) of the heart at a position downstream of the LBBB with respect to a direction of electrical conduction through the LV using the second pacing device after stimulating the His bundle.

Method of cardiac resynchronization therapy

A ventricular assist system including an implantable rotary pump, a pump drive circuit for supplying power to the pump, and a signal processing circuit receiving one or more electrophysiological signals and one or more physiological signals of the subject. The signal processing circuit is operable to receive inputs from the one or more electrophysiological sensors and the physiological sensor, and determine the presence or absence of a non-normal sinus cardiac rhythm condition based on the input from the electrophysiological sensors. In the presence of a non-normal sinus rhythm, the circuit operates the pump in a modified mode of operation. In the absence of a non-normal sinus rhythm, the circuit operates the pump in a normal mode of operation. In either case, the circuit controls the power to the pump and/or speed of the pump based on the input from the physiological sensor and the mode of operation.

Physiologically responsive VAD for cardiac events

A circulatory assist system is disclosed, the system including an implantable electrical device having an electric motor, an implantable controller connected to the implantable electrical device, and an implantable power source connected to the controller for supplying power to the controller. The controller is attachable to a first side of a percutaneous connector. A second side of the percutaneous connector, opposite to the first side, allows external connectivity to said controller.

Hard-wired implanted controller system

A ventricular assist device incorporating a rotary pump configured to be in fluid communication with a heart and systemic circulation of a subject to assist blood flow from the heart to the systemic circulation. The device includes a pump drive circuit for applying power to the pump, one or more sensors for sensing one or more electrogram signals (such as subcutaneous pre-cordial electrode signals) in the patient, and a signal processing circuit to determine the presence or absence of a reduction in cardiac blood flow, ischemic condition or myocardial infarction condition based on subcutaneous pre-cordial electrode signals, to control power supplied to the pump from the pump drive circuit, and to operate the pump in either a normal sinus rhythm mode in the absence of an ischemic condition or myocardial infarction condition, or a modified mode of operation in the presence of an ischemic condition or myocardial infarction condition.

Physiologically responsive blood pump for ischemia detection and treatment

A blood pump incorporating a rotary pump such as a rotary impeller pump implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device may include a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as subcutaneous, pre-cordial ECG signals and a signal processing circuit connected to the sensors and to the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump may run in a normal sinus rhythm mode, with a varying speed synchronized with the cardiac cycle. When an ischemic or myocardial infarction condition is detected, the pump drive circuit may also run the pump in an ischemia or myocardial infarction mode different from the normal sinus rhythm mode.

Blood pump for ischemia detection and treatment

A TET system is operable to vary an amount of power transmitted from an external power supply to an implantable power unit in accordance with a monitored condition of the implantable power unit. The amount of power supplied to the implantable power unit for operating a pump, for example, can be varied in accordance with a cardiac cycle, so as to maintain the monitored condition in the power circuit within a desired range throughout the cardiac cycle.

TET system for implanted medical device

A ventricular assist device incorporating a rotary pump, such as a rotary impeller pump is implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit connected to the sensors and the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a pulsatile mode, with a varying speed synchronized with the cardiac cycle. When an arrhythmia is detected, the pump drive circuit may also run the pump in an atrial arrhythmia mode or a ventricular arrhythmia mode different from the normal pulsatile mode.

Physiologically responsive VAD

A ventricular assist device incorporating a rotary pump () such as a rotary impeller pump implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit () supplying power to the pump, one or more sensors () for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit () connected to the sensors and to the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a normal sinus rhythm mode, with a varying speed synchronized with the cardiac cycle. When a bradycardia arrhythmia is detected, the pump drive circuit may also nm the pump in a sinus bradycardia mode or a heart block mode different from the normal sinus rhythm mode.

Blood pump for treatment of bradycardia

A ventricular assist device incorporating a rotary pump, such as a rotary impeller pump is implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit connected to the sensors and the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a pulsatile mode, with a varying speed synchronized with the cardiac cycle so that it operates in copulsation or counterpulsation with the cycle. The cardiac cycle for purposes of synchronization can also be based on an average of two or more cardiac cycles.

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Marblehead, MA, United States of America

Barry Mitchell Yomtov