Sachem, Inc.

Barry L Haymore

Charles B Little

Ari K Kar

Sara S Moghaddam

Victor Van De Pas

A metal-chelating resin includes (a) a compound represented by Formula (I): or a stereoisomeric form thereof or a salt thereof, wherein R, R, R, R, R, R, Rand Rare as defined herein; and (b) an organic polymer resin having at least one complementary reactive functional group covalently linked with at least one linking group of the compound represented by Formula (I).

Strong binding metal-chelating resins

Strong binding metal-chelating resins using macrocycle molecules

A process for separating organic compounds from a mixture by reverse-phase displacement chromatography, including providing a hydrophobic stationary phase; applying to the hydrophobic stationary phase a mixture comprising organic compounds to be separated; displacing the organic compounds from the hydrophobic stationary phase by applying thereto an aqueous composition comprising a non-surface active hydrophobic neutral zwitterionic displacer molecule and optionally an organic solvent; and collecting a plurality of fractions eluted from the hydrophobic stationary phase containing the separated organic compounds; in which the non-surface active hydrophobic neutral zwitterionic displacer molecule comprises a hydrophobic zwitterion having the general formula, as defined in the disclosure: [CM-R*&#x2014;CM'].

Neutral zwitterionic displacer molecules for hydrophobic displacement chromatography

A displacement chromatography process, including: loading onto a stationary phase comprising an anion-exchange material a mixture comprising one or more components to be separated; and displacing at least one of the one or more components from the stationary phase by applying to the stationary phase a mixture comprising an polyaromatic polyanionic displacer compound having a general formula Cen(Ar), in which Cen is a central bond or group, Ar is an aromatic nucleus, w=2 to the maximum number of sites one Cen, and Ar is substituted with a plurality of An, in which each Anis independently defined as sulfonate, carboxylate, phosphonate, phosphate, sulfate; and Ar is further substituted with a plurality of G, in which G is defined as independently H, C-Calkyl, halogen, nitro, hydroxy, or C-Calkoxy. In addition, a group of polyaromatic polyanionic displacer compounds useful in the process is disclosed.

Anion-exchange displacement chromatography process and anionic organic compounds for use as displacer compounds in anion-exchange displacement chromatography process

A method of buffering a chemical or biological composition, comprising adding to the composition an effective buffering amount of at least one protonated or un-protonated amine-quaternary ammonium compound having a general formula: wherein the variables R, G, n and k are as defined herein.

Buffer compounds

A displacement chromatography process and displacer compounds used in the process and having the general formula (I): wherein:

Cation-exchange displacement chromatography process and cationic organic compounds for use as displacer compounds in cation-exchange displacement chromatography process

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Austin, TX, United States of America

Barry L Haymore