Biotica Technology Limited

Neurovive Pharmaceutical Ab

Dow Agrosciences LLC

Isomerase Therapeutics, Ltd.

Buck Institute for Research on Aging

The University of Oviedo

Abliva Ab

Barrie Wilkinson

Steven James Moss

Matthew Alan Gregory

Christine Janet Martin

Steven Gary Kendrew

Mingqiang Zhang

Rose Mary Sheridan

Paul Richard Graupner

Clive Waldron

Paul Lewer

William A Vousden

Lesley S Burns

Christoph Hendrik Beckmann

Peter Francis Leadlay

Jose A Salas

Carmen Mendez

Carlos Olano

Cesar Sanchez

Alfredo F Brana

Marko Oliynyk

Paul R Graupner

Lesley S Sheehan

A method for increasing the molecular diversity of polyketides and non-ribosomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding the polyketide or peptide.

Methods for increasing molecular diversity of polyketides and non-ribosomal proteins

Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Rapamycin analogues and their pharmaceutical use

There is provided inter alia a compound of formula (I) or a pharmaceutically acceptable salt thereof and its use in therapy. 

Rapamycin analogue

There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.

Sanglifehrin derivatives and methods for their production

There is provided inter alia compounds of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Macrocyclic compounds and methods for their production

There are provided inter alia compounds of formula (I) useful as cyclophilin inhibitors.

Sanglifehrin based compounds

There is provided inter alia a compound of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Compound and methods for its production

The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning into produce the spinosyns, and methods of controlling insects using the spinosyns.

Spinosyn-producing polyketide synthases

The present invention relates to 39-desmethoxyrapamycin derivatives and their uses thereof. The present invention provides for the use of these compounds in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

39-desmethoxy derivatives of rapamycin

The present invention relates to novel 39-desmethoxy-39-methylrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxy-39 -methylrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

39-desmethoxy-39-methyl derivatives of rapamycin

The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials and methods including enzyme systems, nucleic acids, vectors and cells are provided for the preparation of polyketides including borrelidin and analogues and derivatives thereof. Novel polyketide molecules are also provided.

Growing community of inventors

Cambridge, United Kingdom

Barrie Wilkinson