Astrazeneca Ab

Barrie Martin

Paul Andrew Willis

Simon David Guile

Piotr Antoni Raubo

Richard Evans

Bryan Glyn Roberts

Rhonan Lee Ford

Toby Thompson

Stephen Anthony St-Gallay

Matthew Hallam

Christine Eyssade

The present invention relates to isoquinolinone derivatives of formula (I): wherein R, R, R, R, R, Rand Rare as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Compounds and their uses 707

The invention provides compounds of formula (IA), processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. 

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The invention provides novel substituted cyclopentane compounds (in particular, substituted [1,2,3]triazolo[4,5-d]pyrimidines), their use as medicaments (in particular, their use as anti-thrombotic agents), compositions containing them and processes for their preparation.

Substituted [1,2,3]triazolo[4,5-d]pyrimidines

The invention provides a compound of formula (I):wherein Ris alkyl Cor alkenyl C, both independently optionally substituted by one or more groups selected from alkyl Cor halogen; Ris cycloalkyl C, optionally substituted by R; Ris phenyl, optionally substituted by one or more groups selected from alkyl Cor halogen; Rand Rare alkyl Cor together cycloalkyl C. These compounds are useful for the treatment of stable and unstable angina.

2,3,4-cyclopentan-2,3,4-triol-1-yl compounds

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Leicestershire, United Kingdom

Barrie Martin