Glaxo Group Limited

Barrie E Kirk

Keith Biggadike

Alan D Borthwick

Panayiotis Alexandrou Procopiou

Barry C Ross

Nigel Stephen Watson

Richard Storer

Niall G Weir

Anthony D Baxter

Michael G Lester

Chi L Mo

Derek Norman Evans

David A Borthwick

Leslie Stephenson

Certain novel imidazole derivatives N-substituted by a vinyl group itself carrying a mevalonic acid derivative or corresponding lactone are inhibitors of HMG-CoA reductase and are useful for lowering blood plasma cholesterol levels. The compounds are of general formula (I): ##STR1## in which one of the groups R.sup.1 and R.sup.2 represents a C.sub.1-6 alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl ring optionally substituted by one to five substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, S(O).sub.n C.sub.1-3 alkyl, (CH.sub.2).sub.m NR.sup.a R.sup.b, (CH.sub.2).sub.m NR.sup.c COR.sup.d and trifluoromethyl groups;

Imidazole derivatives, pharmaceutical compositions and use

The present invention provides a compound of formula (I) ##STR1## and salts and solvates and pharmaceutically acceptable derivatives thereof, and describes processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of viral diseases, especially those caused by the Herpetoviridae.

Carbocyclic analogues of 7H-1,2,3-triazolo [4,5-d]pyrimidine furanosides

The present invention provides a compound of formula (I) ##STR1## and salts and solvates thereof, and describes processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of viral diseases, especially those caused by the Herpetoviridae.

Guanine derivatives

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Ickenham, United Kingdom

Barrie E Kirk