Beecham Group Plc

Barrie C Cantello

Derek R Buckle

Harry Smith

Richard M Hindley

Frank Peter Doyle

David Haigh

Peter T Duff

Susan M White

Dioxothiazolidine compounds

A compound of formula (I): ##STR1## or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein:

Compounds

A compound of formula (I): ##STR1## or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, wherein:

Novel thiazolidinediones

Compounds of formula (I): ##STR1## or a salt thereof, in which W is phenyl optionally substituted by halogen or trifluoromethyl, or a benzofuran-2-yl group,

Morpholine derivatives, compositions and medicinal uses

Morpholine derivatives, compositions and method of use

A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, in which: W is an optionally substituted phenyl group of the formula ##STR2## wherein R.sup.1 is hydrogen or fluorine, R.sup.2 is hydrogen, C.sub.1-6 alkyl, halogen or trifluoromethyl; or W is a phenoxymethyl or benzofuran-2-yl group;

Secondary amines and use in pharmaceutical compositions

Compounds of formula (II): ##STR1## or salt thereof; wherein R.sup.1 is hydrogen or methyl,

Secondary amines

Morpholine derivatives, compositions and medicinal use

A compound, with hypoglycaemic activity, having formula (II) or a pharmaceutically acceptable acid addition salt thereof: ##STR1## wherein X represents oxygen or sulphur;

Method of treating diabetes using oxazoline or thiazoline compounds

A compound with hypoglycaemic activity having formula (II) or a pharmaceutically acceptable ammonium or acid addition salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy or halogen;

Benzimidazoline derivatives and pharmaceutical compositions containing

A compound of formula (II) or a pharmaceutically acceptable acid addition salt thereof ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents C.sub.1-6 alkyl; R.sup.5 represents hydrogen or C.sub.1-6 alkyl; R.sup.6 represents C.sub.1-6 alkyl, phenyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl, and C.sub.1-6 alkoxy; or benzyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl and C.sub.1-6 alkoxy; or R.sup.5 and R.sup.6 together represent the remaining members of a 5- or 6-membered ring optionally containing an oxygen, sulphur or additional nitrogen atom and being optionally substituted with C.sub.1-6 alkyl, carboxy or C.sub.1-6 alkoxycarbonyl; and R.sup.7 represents C.sub.1-6 alkyl, phenyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl and C.sub.1-6 alkoxy; or benzyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl and C.sub.1-6 alkoxy, has useful hypoglycaemic activity.

Carboxamidine derivatives and hypoglycemical use

A compound, with hypoglycaemic activity, having formula (II) or a pharmaceutically acceptable quaternary ammonium or acid addition salt thereof: ##STR1## wherein X represents oxygen or sulphur;

Intermediates for heterocyclic imines having hypolipidaemic activity

A compound, with hypolgycaemic activity, having formula (II) or a pharmaceutically acceptable quaternary ammonium or acid addition salt thereof: ##STR1## wherein X represents oxygen or sulphur; n.sub.7 represents zero or 1;

Heterocyclic compounds and pharmaceutical use

A class of 4-hydroxy-3-nitrocarbostyril derivatives are useful in the inhibition of certain types of antigen antibody reactions.

4-Hydroxy-3-nitro-carbostyril compounds

A novel class of 3-tetrazole coumarins have anti-allergic activity. They are prepared by the action of ammonium azide on 3-cyano compounds.

Growing community of inventors

Redhill, United Kingdom

Barrie C Cantello