Burroughs Wellcome Co.

Glaxo Wellcome Inc.

Other

Barrett R Cooper

James L Kelley

David Lee Musso

Jeffrey Leaman Selph

Virgil L Styles

Gregory Cooksey Rigdon

Gloria Faye Orr

Ed Williams McLean

Lawrence Edward Brieaddy

Grady Evan Boswell

Daniel Peter McGee

Morton Harfenist

Helen Lyng White

Claudia E Hollingsworth

Provided are compositions comprising an opiate analgesic and an active compound containing the R isomer of N-methylnalorphine in a pharmaceutically acceptable carrier. Also provided are methods of treating opiate intolerance by administration of an active compound containing R N-methylnalorphine or a pharmaceutically acceptable salt thereof. The active compound may administered either acutely or chronically to subjects receiving opiate treatment. Further provided are methods of inducing analgesia by administering to a subject an opiate analgesic concurrently with an active compound containing R N-methylnalorphine or a pharmaceutically acceptable salt thereof.

Methods for treating opiate intolerance

Novel compounds of formula (1) together with their salts and solvates have a number of uses in medicine, in particular as central muscle relaxants.

Bicyclic amide derivatives and their use as muscle relaxants

Amide derivatives and their therapeutic use

1-Ethylphenoxathiin 10,10-dioxide (I) ##STR1## inhibits monoamine oxidase-A and is useful in the treatment of disorders such as depression.

Pharmacologically active compound and use

Novel (2S, 3S, 5R) morpholinols of formula (I) ##STR1## together with the (+-)-(2R*,3R*,5S*) racemates thereof, and their salts, wherein

Heterocyclic pharmaceutical compounds and use

A class of halogen-substituted diphenylsulfide compounds are disclosed which produce a large selective inhibition of serotonin uptake in brain. Such compounds are useful in the treatment of depression, anxiety, obsessive compulsive disorders and substance abuse disorders such as alcoholism.

Medical uses of halogen substituted diphenylsulfides

Growing community of inventors

Durham, NC, United States of America

Barrett R Cooper