Shire LLC

George Mason University

Other

New River Pharmaceuticals Inc.

Barney Bishop

Travis C Mickle

Thomas Piccariello

James Scott Moncrief

Suma Krishnan

Christopher Lauderback

Bernhard J Paul

Christopher Verbicky

Robert A Oberlender

Monique Van Hoek

Lance A Liotta

Emanuel Petricoin

Alexis Patanarut

Rob Oberlender

Alessandra Luchini

Keith M Davies

Mrinalini Ramanan

Francesco Meani

Claudia Fredolini

Thomas M Dunlap

Virginia Espina

Alessandra Luchini Kunkel

Ezra Myung Chul Chung

Nancy Johnston Boerth

Stephanie Barksdale

Caterina Longo

Saswata K Sahoo

Justin Davis

Yaling Zhu

Christopher A Verbicky

Cells and lipid-based structures are described herein, in particular cells and lipid-based structures comprising membrane portions derived from cells having a label covalently attached thereto, as are compositions and kits comprising such cells and structures, and methods for using the cells and structures, in particular for determining membrane coverage and/or orientation as well as for screening methods/assays, and the like.

Membrane coverage and orientation and methods, compositions, and kits related thereto

Peptides are described herein, in particular peptides having antimicrobial properties, as are compositions, articles, and kits comprising such peptides, and methods for using the peptides.

Antimicrobial peptides and compositions, methods, articles and kits relating thereto

Molecularly imprinted particles comprising a label are described herein, in particular such particles prepared by RAFT polymerization, as are compositions and kits comprising such particles, and methods for preparing and using such particles.

Molecularly imprinted particles

Peptides and conjugates are described herein, including peptides having antimicrobial and/or anticancer properties, as are compositions, articles, and kits comprising such peptides and conjugates, and methods for using the peptides and conjugates.

Antimicrobial and anticancer peptides and conjugates and compositions, methods, articles and kits relating thereto

Peptides having antimicrobial properties are described herein, as are compositions containing such peptides, and methods for using the peptides.

Antimicrobial peptides with wound healing activity

Materials and methods for making and using cationic anti-microbial peptides (CAMPs), and compositions containing such peptides.

Antimicrobial peptides and uses therefore

A cationic antimicrobial peptide (CAMP) conjugate is disclosed. The CAMP conjugate may be made by identifying a suitable carrier peptide; identifying a suitable antimicrobial agent; creating a conjugate by conjugating the peptide with the antimicrobial agent; and evaluating and refining the conjugate. The peptide may be short peptide based on the sequence of a CAMP, such as human &#x3b2;-defensin-3. The peptide can be directly connected to the antimicrobial agent or through a linker segment. The antimicrobial agent may be connected to the peptide or the linker segment through stable or cleavable bonding. The peptide may carry and facilitate the delivery of the conjugated antimicrobial agent to a microbe.

Targeted delivery of antimicrobial agents

Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.

Method for harvesting nanoparticles and sequestering biomarkers

Smart hydrogel particles for biomarker harvesting

The invention provides a 'street-safe' version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.

Carbohydrate conjugates to prevent abuse of controlled substances

The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

Abuse-resistant amphetamine prodrugs

Growing community of inventors

Annandale, VA, United States of America

Barney Bishop