Research, Incorporated

Other

Michigan State University

Research Corporation Tech., Inc.

Barros Research Institute

Barnett Rosenberg

James P Davidson

Thomas Krigas

Loretta L Van Camp

Ronald W Hinz

Loretta Vancamp

John W Judge

James D Hoeschele

Michael J Cleare

Charles Aylsworth

Siu-Cheong Ho

Igor V Zlatkin

Tatiana Zlatkin

David Juckett

Trygve Aaby

Henry J Peresie

Samir Kansy

David A Juckett

Robert G Ficher

Laurence A Fishel

Devinder S Gill

The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.

Compositions and methods for immunotherapy of cancer and infectious diseases

The present invention relates to methods of treating or preventing a disease, disorder or condition associated with a viral infection using a dosing and resting regimen for administering a pharmaceutical composition that provides ARP.

Methods of treating or preventing a disease, disorder or condition associated with a viral infection

Malignant tumors in animals are treated by parenterally administering to an affected animal a solution containing a complex compound of platinum in an amount effective to cause regression of the tumor.

Anti-tumor method

Described is a method of preparing polyacrylamide gel containing capillary tube wherein acrylamide is polymerized from a liquid to a gel within the tube, the improvement comprising the steps of: a) after the polymerization, annealing the gel inside the tube by cycling the gel/tube at least once in a temperature range from 20.degree. C. to a temperature not to exceed about 75.degree. C. and back to ambient; and b) recovering the stress released gel-filled tube. Preferably, the polymerization commences at the middle of the tube and commences toward the extremities of the tube.

Method of preparing gel containing capillaries

An analgesia composition comprising an aqueous solution of a neurologically active agent in a concentration of from about 10.sup.-3 to about 10.sup.-13 grams/ml and a method of relieving pain comprising topically applying the composition to the genitalia of a human or non-human animal.

Analgesic composition and method of relieving pain

Malonato platinum coordination compounds and a method of treating malignant tumors sensitive to a planar dsp.sup.2 platinum (II) coordination compound or an octahedral d.sup.2 sp.sup.3 platinum (IV) coordination compound comprising the parenteral administration to an affected animal of a solution of the compound.

Malonato platinum compounds

Palladium complexes and pharmaceutical compositions containing palladium complexes adapted for the treatment of tumors cells sensitive to the palladium complexes and methods of treating tumor cells using the palladium complexes are disclosed.

Palladium anti-cancer complexes

A method for treating animals afflicted with a viral infection comprising the administration to the animal of a platinum coordination compound.

Method of treating viral infections

A platinum-[2,4-dioxopyrimidine] complex and pharmaceutical composition suitable as an anti-tumor, anti-bacterial and anti-viral agent and process for the manufacture thereof comprising reacting a 2,4-dioxopyrimidine having the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are suitable substituents with cis-diaquodiamineplatinum (II).

Platinum-dioxopyrimidine complexes

A portable microprobe uses 10 gigahertz CW microwave radiation at a power level of less than 10 milliwatts for recording of a number of biophysical phenomena associated with the cardiac and neural activity of the life system. The microprobe consists of a Gunn diode feeding power into a short, insulated dielectric waveguide, the free end of which houses a point contact semiconductor diode isolated by a metal shield from the incident beam. The wave guide concentrates and delivers a pencil shaped beam into the tissue of interest and the back-scattered radiation is modulated and detected by the diode. The detected signal is filtered, amplified and recorded to reflect on-going biological activity. The receiver electronics is housed in a small self-contained package and has its output connected through a flexible attachment to two ear tubes which enable continuous monitoring of the audio response through an electrical and audio converter indicative of the on-going biological activity. By scanning step wise across the chest, the microprobe allows localization of many details of cardiac activity. The microprobe can also be used to monitor activities of the brain and the spinal cord.

Microprobe for monitoring biophysical phenomena associated with cardiac

Malignant tumor cells sensitive to platinum coordination compounds in animals are treated by parenterally administering to an affected animal a solution containing a complex compound of platinum in an amount effective to cause regression of the tumor.

Anti-animal tumor method

Malonato platinum coordination compounds and a method of treating malignant tumors comprising the parenteral administration to an affected animal of a solution of the compound.

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Holt, MI, United States of America

Barnett Rosenberg