Mayo Foundation for Medical Education and Research

Barham K Abu Dayyeh

Samuel J Asirvatham

Christopher V DeSimone

Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.

Electroporation for obesity or diabetes treatment

Cystic lesions can be treated by electroporation. For example, this document describes methods and devices for endoscopic ultrasound-guided ablation of cystic lesions using a needle for electroporation.

Endoscopic ultrasound electroporation

A system for bypassing a portion of a small intestine. The system includes an occlusion device and a bypass device. The occlusion device includes a tubular body, an occlusion member at a distal end portion of the tubular body, and an anchor member at a proximal end portion of the tubular body. The bypass device includes a liner, and an anchor member at a proximal end portion of the liner.

Methods and devices for gastricintestinal tract bypass

Devices and methods can be used for the endoscopic treatment of conditions such as obesity and metabolic diseases. For example, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake. The devices provided herein can be endoscopically implanted such that direct visualization of the entire implant location within the gastrointestinal tract is attained. In some embodiments, the device is distally deployed utilizing a technique that is like that of single or double-balloon enteroscopy.

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Rochester, MN, United States of America

Barham K Abu Dayyeh