Columbia University

Barclay Morrison, Iii

Ioannis Kymissis

Patricia A Walker

Catherine A Schevon

Benjamin Simon Elkin

John Desmond Finan

James M Noble

Steve Kernie

The current invention is a method of treating, preventing, reducing and/or abolishing edema and/or intracranial pressure in a subject by the administration of hyaluronidase. The edema in the brain and intracranial pressure can be the result of a traumatic event, disease or condition including but not limited to a traumatic brain injury, a stroke, a brain tumor, and post-operative swelling.

Hyaluronidase for the prevention, treatment, reduction and/or abolishment of cerebral edema and intracranial pressure

Systems and methods for detecting concussions in real-time are provided. An exemplary system of detecting concussions in real time includes an accelerometer to measure acceleration event and generate an accelerometry signal. The system includes a plurality of electrodes to detect an electroencephalogram (EEG) and each of the electrodes can be attached to a top region of the headgear through a flexible shaft. The system further includes a signal processing circuit to amplify, filter and broadcast an electroencephalogram (EEG) signal to a local wireless receiving unit.

Systems and methods for real-time concussion diagnosis by electroencephalogram activity monitoring

Tissue fixed charge density (FCD) is identified as another potential therapeutic target for reducing brain tissue swelling. Reduction of the FCD could reduce the thermodynamic force driving water entry into the brain. The present invention discloses chondroitinase ABC (ChABC) reduces tissue FCD and reduces tissue swelling, indicating that it may be an effective treatment to reduce edema and control intracranial pressure.

Enzyme combinations to reduce brain tissue swelling

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New York, NY, United States of America

Barclay Morrison, Iii