Ab Kabi

Barbro K Goransson-Dahlander

Nils A Jonsson

Ferenc Merenyi

The present invention relates to new pharmacodynamically active compounds of the general structure ##STR1## as well as the corresponding amine oxides, quarternary ammonium compounds and salts with physiologically acceptable acids. In formula I R.sup.1 signifies hydrogen, halogen or alkoxy radicals having 1-3 carbon atoms, R.sup.2 and R.sup.3 signify alkyl radicals having 1-3 carbon atoms, which togetner with the carbon atom, to which they are connected, may form a ring, A either signifies a possibly lower alkyl substituted ethylene, trimethylene or tetramethylene group, in which case D is a group ##STR2## wherein R.sup.4 and R.sup.5 individually signify hydrogen or alkyl groups having 1-4 carbon atoms, or together with the nitrogen atom form a heterocyclic ring, which in addition to said nitrogen atom may contain an oxygen atom or possibly lower alkylated amino group, or A and B taken together signify a piperidino- or N-lower alkylpiperidino group, which is connected to an indene residue in 4-position, and the broken lines signify a double bond in either endo- or exo position.

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Farsta, Sweden

Barbro K Goransson-Dahlander