Nerviano Medical Sciences S.r.l.

Genentech, Inc.

Genetech, Inc.

Barbara Valsasina

Italo Beria

Michele Caruso

Paul Polakis

John A Flygare

Andrew G Polson

Susan D Spencer

Matteo Salsa

Vittoria Lupi

Rita Perego

Maria Gabriella Brasca

Robert L Cohen

Helena Posteri

Marina Caldarelli

Dario Ballinari

Enrico Pesenti

Ron Ferguson

Walter Ceccarelli

Antonella Ciavolella

Valter Domenico Croci

Juergen Moll

The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.

Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds

The present invention provides a combination comprising (a) a compound of formula (I) and (b) one or more antineoplastic agents selected from the group consisting of an antimetabolite agent, analkylating or alkylating-like agent, an intercalating agent, a topoisomerase I or II inhibitor, an antimitotic agent, a kinase inhibitor, a proteasome inhibitor and an antibody inhibiting a growth factor or its receptor, wherein active ingredients of the combination are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate or solvate thereof, useful in the treatment of tumors. 

Therapeutic combination comprising a PLK1 inhibitor and an antineoplastic agent

Pyrazolo-quinazoline derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. 

Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors

Substituted pyrrolo-pyrimidine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer. 

Substituted pyrrolo-pyrimidine derivatives, process for their preparation and their use as kinase inhibitors

Growing community of inventors

Milan, Italy

Barbara Valsasina