Centre National De La Recherche Scientifique

Université Paris—sud

Universite Paris Su Xi

Université Paris Sud Xi

Barbara Stella

Patrick Couvreur

Luigi Cattel

Flavio Rocco

Jack-Michel Renoir

Véronique Rosilio

Harivardhan Reddy Lakkireddy

Franco Dosio

The invention relates to a water-dispersible derivative of a therapeutic agent having a low water solubility that comprises at least one molecule of said agent covalently bonded to at least one molecule of a hydrocarbon derivative having a squalenic structure or the like. The invention further relates to corresponding nanoparticles.

Nanoparticles of therapeutic agents having low water solubility

The use of squalenic acid or a derivative thereof in formulating at least one polar active principle with a molecular weight of 100 Da or more, in the form of nanoparticles, and pharmaceutical compositions thereof.

Nanoparticle derivatives of gemcitabine

The invention concerns a 2',2&#x2032;-difluoro-2&#x2032;-deoxycytidine derivative of general formula (I), wherein: R, Rand R, identical or different, represent independently of one another, a hydrogen atom or an at least Chydrocarbon acyl radical and of such conformation that it is capable of providing the compound of general formula (I), a compacted form in a polar solvent medium, at least one of groups R, Rand Rbeing other than a hydrogen atom.

Gemcitabine derivatives nanoparticles

Growing community of inventors

Turin, Italy

Barbara Stella