Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Barbara Steiner

Jacek Biernat

Eckhard Mandelkow

Gerard Drewes

Birgit Lichtenberg-Kraag

Eva-Maria Mandelkow

Eva-Marie Mandelkow

The invention relates to epitopes of the tau protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.

Tools for the diagnosis and treatment of Alzheimer's disease

The present invention relates to phosphorylated tau protein epitopes associated with Alzheimer's disease, to protein kinases responsible for tau protein epitope phosphorylation, and to antibodies specific for the tau epitopes. Additionally, the present invention relates to pharmaceutical compositions, methods for detection, and methods of testing drugs effective in dissolving paired helical filaments associated with Alzheimer's disease.

The invention relates to epitopes of the protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.

Growing community of inventors

Ludwigshafen, Germany

Barbara Steiner