Hoechst Roussel Pharmaceuticals

Hoechst Marion Roussel

Aventis Pharmaceuticals Inc.

Sanofi

Aventis Hoklings Inc.

Hoescht Roussel Pharmaceuticals Inc.

Barbara S Rauckman

Gregory H Merriman

Brian S Freed

John J Tegeler

Russell R Hamer

Russell R Harner

Raymond W Kosley, Jr

Nicholas J Hrib

David Fink

George Lee

Russell R Harmer

Thomas B Lee

Zhongli Gao

Sukanthini Thurairatnam

Brian L Pedgrift

John Ziqi Jiang

Jeffrey Stephen Sabol

Christopher Loren Vandeusen

Stanly John

Suzanne C Aldous

Lan Mu

Christopher L Vandeusen

Russell R Hanner

Russell Richard Lee Hamer

Grzegorz T Stoklosa

James R Pribish

Michael W Fennie

Thomas Bk Lee

This invention is directed to a compound of formula (I): wherein R, R, R, Rand Lare as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma and/or chronic obstructive pulmonary disease (COPD).

Pyrimidine hydrazide compounds as PGDS inhibitors

The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as Dantagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of Dreceptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.

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Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.

1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino 1,3-propanediols and related compounds

1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino- 1,3-propanediols and

This invention relates to 3-aryl-2-(1-substituted-4-piperidinyl)-1,1-dioxo-3H-benzo[d]isothiazoles and related compounds of the formula, ##STR1## where X and Y are independently halogen, loweralkyl, loweralkoxy, arylloweralkoxy, acyl, hydroxy, nitro, amino, trifluoromethyl and hydrogen; n, p and q are independently integers of 1 or 2; R is hydrogen, loweralkyl, aryloweralkyl, acyl, --(CH.sub.2).sub.m --OR.sub.1,--(CH.sub.2)NHR.sub.1, ##STR2## where R.sub.1 is hydrogen, loweralkyl, arylloweralkyl, acyl and loweralkoxycarbonyl; Z is hydrogen, halogen, loweralkyl, loweralkoxy and acyl; m is an integer of 2 to 4; is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof and the optical isomers thereof where such isomers exist.

3-aryl-2-(1-substituted 4-piperidinyl)-1,1-dioxo-3H-benzo[D]isothiazoles

The present invention relates to a novel process for the preparation of physostigmine carbamate derivatives and to pharmaceutically acceptable salts thereof. The present invention further relates to a novel process for the preparation of eseroline derivatives and to pharmaceutically acceptable salts thereof.

Method of preparation of physostigmine carbamate derivatives from

1-alkyl-,1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and

1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and

1-Alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and

1-alkyl-, 1-alkenyl-, and 1-alkylnlaryl-2-amino-1,3-propanediols and

Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth fire disclosed.

1-alkyl-, 1-alkenyl-, and 1-alkynlaryl-2-amino-1, 3-propanediols and

Growing community of inventors

Flemington, NJ, United States of America

Barbara S Rauckman