Eli Lilly and Company

Barbara S Briggs

Milton J Zmijewski

Milton Zmijewski, Jr

Robin D Cooper

Tony Yantao Zhang

James P Kanter

James A Aikins

Gerd Ruhter

Uko Effiong Udodong

Adam Joseph Kreuzman

John J G Mullins

Milton Joseph Zmijewski, Jr

Daniel Verral, Ii

Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are enzymatic processes for resolving chiral intermediates or final products to provide desired enantiomers.

Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor

This invention provides processes for preparing intermediates useful for the preparation of cryptophycin compounds.

Stereoselective process for producing intermediates of cryptophycins

The present invention is directed to deacyl teicoplanin, and to a process for preparing deacyl teicoplanin by reacting teicoplanin with ECB deacylase. Deacyl teicoplanin can be alkylated to produce compounds useful for their antibacterial activity.

Teicoplanin deacylation process and product

Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides said phthalyl amidase, means for producing it by culturing the natural organism from which the activity was identified, and methods for using said phthalyl amidase to remove the phthalyl moiety from phthalyl-containing amides.

Enzyme from microbial source: phthalyl amidase

The present invention provides a biotransformation process for preparing a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or a .beta.-glucuronide group of the formula ##STR2## provided at least one of R.sub.1 and R.sub.2 is a .beta.-glucuronide group.

Process for preparation of benzo[B]thiophene glucuronides

Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides 2 phthalyl amidase, 2 method for producing it by culturing the natural organism from which the activity was identified, and methods for using the phthalyl amidase to remove the phthalyl moiety from phthalyl-containing amides. The ezyme is isolated from Xanthobacter agilis.

Phthalyl amidase-producing Xanthobacter agilis

Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides a phthalyl amidase, a method for producing it by culturing the natural organism from which the activity was identified, and methods for using the phthalyl amidase to remove the phthalyl moiety from phthalyl-containing amides. The enzyme is isolated from Xanthobacter agilis.

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Indianapolis, IN, United States of America

Barbara S Briggs