Burroughs Wellcome Co.

Other

Barbara Roth

Barbara S Rauckman

Susan Mary Daluge

Alistair Allen Miller

Paul M Skonezny

David Albert Sawyer

Compounds of the formula (II) ##STR1## or a salt, N-oxide or acyl derivative thereof, wherein Y is a group ##STR2## which is linked to the pyrimidinylmethyl moiety at the 1 or 7-position and is optionally substituted at the 2, 3, 4 or 6-position or at the 7-position when the linkage to the pyrimidinylmethyl moiety is at the 1-position wherein X is an oxygen or sulphur atom, a group CH.sub.2, a group S(O).sub.n where n=1 or 2, a group NR.sup.1 wherein R.sup.1 is hydrogen C.sub.1-4 alkyl or a group COR.sup.2 where R.sup.2 is hydrogen, C.sub.1-4 alkoxy or amino and the dotted line represents a single or double bond, have antimicrobial activity. Processes for making these compounds, pharmaceutical compositions containing them and the medical use of the compounds are also disclosed.

2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials

Compounds of the formula (II) ##STR1## or a salt, N-oxide or acyl derivative thereof, wherein Y is a group ##STR2## which is optionaly substituted and which optionally contain a nitrogen atom at one of positions A, B, C, D or E, in which the dotted line represents aromatic rings unless one of the rings contains a nitrogen atom in which case this ring is either aromatic or partially saturated, have antimicrobial properties. Processes for making these compounds, pharmaceutical compositions containing them and the medical use of the compounds are also disclosed.

2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or

The medical use of compounds of the formula (III): ##STR1## or pharmaceutically acceptable and addition salts thereof, wherein R.sup.6 is a hydrogen atom, R.sup.5 is a chlorine atom and R.sup.7 is a hydrogen or chlorine atom or R.sup.7 is a chlorine atom, R.sup.5 is a hydrogen atom and R.sup.6 is a chlorine atom, particularly for the treatment of CNS disorders, is disclosed. Solid pharmaceutical compositions are also described.

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Chapel Hill, NC, United States of America

Barbara Roth