Alumend, LLC

Allergan, Inc.

Barbara R Haberer

Ronald E Utecht

Kaia L Kloster

Therese M Downey

Therese J Downey

James Nienyuan Chang

Jeffrey E Elbert

Patrick D Youso

Disclosed are methods for treating stenosis in the digestive system and conditions associated with irregular esophageal tone with dimeric naphthalimide compounds and their pharmaceutically acceptable salts. Also disclosed are methods for enhancing recovery following esophageal surgery that entail treatment of the surgical area with dimeric naphthalimide compounds and their pharmaceutical salts.

Treatment of the gastrointestinal tract with dimeric naphthalimide compounds

Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

Methods of acute restoration of vascular compliance

Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

Compositions and methods of using the compositions for plaque softening

Biomaterials are disclosed having unique properties that make it a useful material in adhesives, local drug delivery applications and as filler or bulking material. The biomaterials are strong, safe and easily used as a surgical adhesive. Treated chitosan, modified chitosan or modified and treated chitosan compositions are disclosed displaying strengths suitable for general surgical applications. The materials can be used as a drug delivery vehicle which allows for the localization of the delivered drug as well as a programmable tether which allows for the release of the drug on a timed basis or in response to a physiological state such as the release of proteolytic enzymes. The materials of this invention can also be modified and treated to optimize the retention of water, thereby serving as a useful filler or bulking material.

Biomaterials and a method for making and using same

Biomaterials and a method for making and using the same

A biomaterial is disclosed having unique properties that make it useful in ocular drug delivery applications, where the drugs selected from the group consisting of a prostaglandin, a prostamide, a non-steroidal anti-inflammatory drug (NSAID), and a corticosteroid, and mixtures, derivatives, salts and esters thereof.

Growing community of inventors

Hartford, SD, United States of America

Barbara R Haberer