Universitat Leipzig

Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet

Eberhard Karls Universitat Tubingen Medizinische F Akultat

Barbara Proksch

Christoph Gleiter

Lusine Danielyan

Gayane Buniatian

Rolf Gebhardt

Matthias Schwab

Richard Schäfer

Christoph Hermann Gleiter

Richard Schaefer

The present invention relates to a method for the in vitro selection of at least one therapeutic cell subpopulation from an original cell population of eukaryotic cells, as well as to the therapeutic cell subpopulation selected by the method, which can be used for the treatment of diseases of tissues or organs. The selected cells are highly migrative and the method according to the invention provides for the selection of these highly migrative subpopulations from a sample comprising a mixture of cells.

Cell selection method and cells obtained therefrom

The present invention relates to a method for the treatment of organs which are degenerative and/or in the pathological state by means of the use of cells, which are phenotypically stably differentiating or differentiated but not necessarily ultimately predetermined with respect to development, from a donor organ selected according to the principles of the opposite cell differentiation program (OCDP) and also to the use of cells of this type for the treatment or for the production of a drug for treatment of the same. Furthermore, the present invention relates to pharmaceutical agents comprising suitable phenotypically stable cells, cells of a first organ which is different from the second organ with respect to organ type thereby being used, which, in the normal physiological state with respect to a predetermined set of expressed genes and/or phenotypical properties, have opposite properties to the second cells in the normal physiological state.

Use of the opposite cell differentiation program (OCDP) for the treatment of degenerated organs in the pathological state

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Tuebingen, Germany

Barbara Proksch