Pierre Fabre Medicament

Nad Ag

Barbara Monse

Thierry Imbert

Wouter Koek

Jean-Pierre Robin

Yves Guminski

Bridget Hill

Laura Casiraghi

Hans-Wolfgang Klafki

Pierfausto Seneci

Heidi Sahagun-Krause

Tobias Braxmeier

Silvia Müller

Olivier Thillaye Du Boullay

Wolfgang Frohner

Sandra Gordon

Valerie Thillaye Du Boullay

Hanno M Roder

The invention concerns compounds of general formula 1, wherein: A, B, D and E represent one or two nitrogen atoms, the others being carbon atoms; X represents a S or, a O, thereby forming a bicyclic fused heteroaromatic, such as thieno[2,3-b]pyridine, furo[2,3-b]pyridine, thieno[3,2-b]pyridine, furo[3,2-b]pyridine, thieno[2,3-b]pyrazine, furo[2,3-b]pyrazine, thieno[2,3-c]pyridine, furo[2,3-c]pyridine, thieno[3,2-c]pyridine and furo[3,2-c]pyridine; R1 represents a linear or branched C-Calkoxy group, a linear or branched C-Calkylthio group; R2 represents a linear, branched, cyclic C-Cgroup, a 2- or 3-thienylmethyl group, or a benzyl group optionally substituted by one or several halogens, F, Cl, Br, I, C-Calkyl, C-Calkoxy, CF3, CN, NO2, OH; and their pharmaceutically acceptable salts. Said compounds are anti-dopaminergic agents. 

3&#x3b2;-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof

This invention relates to N-carbacycle monosubstituted indolocarbazole compounds. Furthermore, this invention relates to medicaments comprising N-carbacycle monosubstituted indolocarbazoles compounds and the use of such compounds for treating non-insulin dependent diabetes mellitus, acute stroke and other neurotraumatic injuries, for treating diabetes mellitus, as a chemotherapeutic for the treatment of various malignant diseases, for treating diseases caused by malfunctioning of specific signaling pathways, and for treating neurodegenerative diseases such as for example Alzheimer's disease.

N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors

Water-soluble derivatives of epipodophyllotoxin, process for their

Naphthamide derivatives of 3-beta-amino azabicyclo octane or nonane as

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Weichs, Germany

Barbara Monse