Lek Pharmaceuticals D.d.

Krka, Tovarna Zdravil, D.d.

Pliva-istrazivanje I Razvoj D.o.o.

Barbara Mohar

Damjan Sterk

Renata Toplak Casar

Rok Zupet

Anton Stimac

Amir Avdagic

Roman Lenarsic

Michel Stephan

Milena Benedik

The invention discloses a process for the preparation of compounds having structures typical for proton pump inhibitors in enantiomerically enriched form by using particular metal catalysts in an enantioselective oxidation step. Also disclosed are useful further processes and pure intermediate and subsequently final products.

Process for the preparation of enantiomerically enriched proton pump inhibitors

The present disclosure relates to an improved process for the preparation of enantiomerically enriched alcohols of Formula (I),  

Form of a benzenesulfonamide derivative

The present invention relates to a new process for the preparation of optically pure(R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin.

Synthesis of optically pure(r)-5-(2-amynopropyl)-2-methoxybenzenesulphonamide

The invention provides an improved process for preparing Olanzapine as well as intermediates therefor.

Process and intermediates for the preparation of olanzapine

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Ljubljana, Slovenia

Barbara Mohar