Giuliani S.p.a.

Guiliani S.p.a.

Giuliana S.p.a.

Nogra Pharma Limited

Barbara Marzani

Giammaria Giuliani

Anna Benedusi

Sergio Baroni

Francesca Viti

Salvatore Bellinvia

Ralf Paus

Antonio Mascolo

Daniela Pinto

Elena Pini

Antonio Limitone

Marco Gobbetti

Raffaella Di Cagno

Benedetto Grimaldi

Fabio Rinaldi

Guido Bregaglio

Jeremy Cheret

Walter Bertin

Raffaella Gandolfi

Yuval Ramot

Nathan Hawkshaw

Pasquale Filannino

Vincenzo Cantatore

Marzia Pellizzato

Mauro Picardo

Giuseppina Maria Fiorino

Ali Zein Alabiden Tlais

Jérémy Cheret

The present invention relates to a biotechnological process for the production of a fermented pollen comprising the inoculation of pollen with at least one lactic bacterium of the speciesand the fermentation of the pollen inoculated with the lactic bacterium. The fermented pollen obtained has nutritional and organoleptic properties similar to bee bread naturally produced inside the honeycomb of the beehive and finds application in the food and nutraceutical field.

Microbiological process for the production of bee bread

The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic administration or the local application to the scalp.

Composition for prevention and treatment of hair growth disorders

The present invention concerns the use of selected compounds in a cosmetic skincare treatment or in the treatment of certain skin, scalp or mucosal diseases. The invention also provides a composition for topical use incorporating a pharmaceutically or cosmetically effective amount of a compound for preventing or treating skin or mucosal diseases having an inflammatory component or for reducing the redness or irritation of skin or mucosae.

Compounds for preventing and treating skin or mucosal affections having an inflammatory component

The present invention concerns a composition comprising aextract orpolysaccharide in combination with aextract and a pharmaceutically acceptable carrier. The composition finds application both in the medical field, in the treatment of actinic lesions, precancerous skin lesions, or non-melanoma skin cancer, and in non-therapeutic applications in the treatment of skin damage caused by exposure to the sun's rays, such as photoaging.

Composition for the prevention and treatment of skin damages caused by photo-exposure

The invention relates to a synergistic composition comprising a dry extract of plant of genusand a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.

Synergistic composition as a promoter of autophagy

The present invention relates to the use of a plant extract from the genusspeciesor a composition that contains it to stimulate hair growth or improve the appearance or hair fullness. The composition containing the plant extract is applied in both cosmetic and medical-trichological fields and can be applied topically on the scalp or administered orally.

Vegetable extract to prevent and treat hair loss

The invention relates to compounds having general formula (I): where R&#x2550;H, CH&#x2014;OH, CH&#x2014;O&#x2014;CO&#x2014;CH, CH&#x2014;O&#x2014;CO-Ph (Ph=phenyl) R'&#x2550;H, CH&#x2014;O&#x2014;CO&#x2014;CH, CH&#x2014;O&#x2014;CO-Ph (Ph=phenyl) Ar=phenyl, 3-methoxy-4-hydroxy phenyl, 2-furyl. These are compounds having antioxidant activity against free radicals together with anti-inflammatory activity, the compounds being useful as active ingredients for the preparation of pharmaceutical dermatological or cosmetic compositions for skin care. 

Compounds having antioxidant activity against free radicals and anti-inflammatory activity, and corresponding pharmaceutical or cosmetic compositions for skin care

The present invention relates to a composition for pharmaceutical, nutritional or cosmetic use, suitable to preserve the physiological condition and health of skin and hair and to reestablish their regenerative functions, characterized in that it comprises a mixture of carnitine, caffeine and arginine as active principle, as such or as derivatives, such as pharmacologically acceptable salts. The effect of preserving the physiologic condition and health of skin and hair, and of reestablishing their regenerative functions is mainly achieved through an increase in ATP production by skin and hair cells.

Composition suitable to preserve the physiological condition of skin and hair and reestablish their regenerative functions

The invention relates to the 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid; its use in the therapeutic and cosmetic field for topical application to the skin to achieve a combined antioxidant activity against ROS together with an anti-inflammatory effect and an effect of promoting the production of hyaluronic acid, so as to oppose at the same time the oxidizing action of free radicals and inflammatory effects, in order to preserve the physiological conditions of human epidermis and skin homeostasis and prevent skin aging (anti-aging); the compositions for therapeutic and cosmetic use which comprise 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid as active ingredient, formulated with excipients for topical use suitable for local administration on the skin.

Active compound and related composition for dermatological use in the pharmaceutical or cosmetic field

The invention relates to a composition for pharmaceutical or nutritional or cosmetic use, formulated for oral or topical use and possessing antioxidant activity against free radicals, comprising: a) aseed, or seed and leaf, extract containing a combination of the flavonoids catechin and quercetin in a molar ratio in a range from 6:1 to 3:1, respectively, or a') aseed, or seed and leaf, extract containing a combination of the flavonoids catechin and quercetin in a molar ratio in a range from 7:1 to 4:1, respectively, or a&#x2033;) a mixture ofextracts a) and a&#x2032;), or a&#x2032;&#x2033;) a mixture of catechin and quercetin in a molar ratio in a range from 7:1 to 3:1, respectively, together with b) an olive,L, leaf extract having a hydroxytyrosol content in a range from 1% to 30% by weight of the extract, or b&#x2032;) hydroxytyrosol in an amount equal to that contained in the b) extract.

Flavonoid-based composition for pharmaceutical, nutritional or cosmetic use having potentiated antioxidant action

The invention relates to 2,4,6-octatrienoic acid derivative compounds having general formula (I) (CH&#x2014;CH&#x2550;CH&#x2014;CH&#x2550;CH&#x2014;CH&#x2550;CH&#x2014;CO&#x2014;O&#x2014;)&#x2014;R (I) consisting of esters wherein n=1, 2, 3 and wherein R is selected from alkyl, aryl or cycloalkyl of a polyol, phenol or phenolic acid; or consisting of a salt wherein n=1 and R=arginine, as active ingredients in a pharmaceutical or cosmetic composition having a combined antioxidant activity against free radicals together with an anti-inflammatory action.

Compounds with a combined antioxidant activity against free radicals together with an anti-inflammatory action, and pharmaceutical and cosmetic compositions containing them for the treatment of skin and hair

The invention concerns the use of compounds with formula (I) R&#x2014;N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) HN&#x2014;(CH)&#x2014;N(R)&#x2014;(CH)&#x2014;NHeither as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.

Composition for cosmetic use suitable to produce a pigmentation effect on hair

The present invention relates, in one aspect, to the use of a composition based on a vegetal extract ofNecker and of a physiologically acceptable carrier in the treatment or prevention of hair loss. The composition finds application in the field of trichology and may be applied topically on the scalp or administered orally.

Use of a vegetal extract for the prevention and treatment of hair loss

A polyglycerol-azelaic acid polyesters and cosmetic compositions that incorporate them as active components in combination with a cosmetically acceptable vehicle. A process for producing esters and polyesters between azelaic acid and glycerol or oligomers thereof containing up to 10 monomer units.

Polyglycerol-azelaic acid polyesters for cosmetic applications

The present invention relates to a cosmetic or pharmaceutical composition for treating alopecia, and in general for counteracting excessive hair loss, comprising as an active ingredient a compound of formula (I) R&#x2014;N-spermidine, or 1,4-butane-diamine,N-(3-aminopropyl)-N&#x2014;R. The compounds of general formula (I) are active in accordance with the objects of the present invention, and also sufficiently stable to allow effective application for topical use on the scalp without potentially being transformed into a different substance, which is no longer active, as a result of oxidation.

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Carbonara al Ticino, Italy

Barbara Marzani