Gen-probe, Inc.

Barbara Lynn Eaton

Damon Kittredge Getman

Traci Pawlowski

Angela S Hudson

Alice Jiang

Ankur Shah

Paul M Darby

Benjamin Grobarczyk

Matthias Jost

Yves Antonius Ozog

Jimmykim Pham

Ankur H Shah

Renaud Close

Laurent Franzil

Samira Barhdadi

Joshua Kalani Moberly

Method of preparing a biological sample appropriate for use in a subsequent in vitro nucleic acid amplification reaction. A biological sample is combined with an alkaline composition that lyses cells and denatures DNA to create a first liquid composition. The first liquid composition is then mixed with a buffer, a detergent, and a solid support that captures DNA to create a second liquid composition. The buffer, detergent, and solid support can be delivered as components of a single reagent. Captured DNA strands can be used as templates in subsequently performed nucleic acid amplification and detection reactions with improved sensitivity.

Sample preparation method and system

Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection ofandnucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

Compositions and methods for detectingandnucleic acid

Disclosed are methods for diagnosing Bacterial Vaginosis in a subject comprising performing an assay for the detection of any one or more ofsp.,, andsp. in a subject sample. Also disclosed are methods and compositions for detectingsp.,, and/ornucleic acid in a sample.

Kits for detecting bacterial nucleic acid

Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of Group B(GBS;) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

Compositions and methods for detecting group Bnucleic acid

Disclosed are methods utilizing specific amplification ofsp. target nucleic acid for detecting the presence or absence ofsp. in a sample. Also disclosed are corresponding oligomers, including amplification oligomers, capture probes and detection probes, and combinations thereof, as well as corresponding reaction mixtures and kits.

Compositions for detectingspecies

Methods for diagnosing and monitoring treatment of bacterial vaginosis

Methods and compositions for detectingspecies

Methods and compositions for detecting bacterial nucleic acid

Growing community of inventors

San Diego, CA, United States of America

Barbara Lynn Eaton