Rutgers, the State University of New Jersey

Memorial Sloan Kettering Cancer Center

University of Bonn

The Rockefeller University

Barbara L Gaffney

Roger A Jones

Thomas Tuschl

Gunther Hartmann

Dinshaw J Patel

Manuel Ascano, Jr

Winfried Barchet

Thomas Zillinger

Pu Gao

Yang Wu

Yizhou Liu

Reza Fathip

Roger Jones

Manuel Ascano

The present disclosure provides, among other things, compounds comprising cyclic dinucleotides containing a 2',5' linkage useful in the design of research tools, as research tools, and as therapeutic modalities such as enzyme modulators.

Compositions and methods for altering second messenger signaling

The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.

The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.

Provided herein are compounds of formula Ia: and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula Ia, processes for preparing compounds of formula Ia, intermediates useful for preparing compounds of formula Ia and therapeutic methods using compounds of formula Ia.

Growing community of inventors

Hillsborough, NJ, United States of America

Barbara L Gaffney