May & Baker, Ltd.

Barbara Joyce Broughton

Stuart Malcolm Marshall

Kenneth Robert Wooldridge

David Lord Pain

Bryan John Large

Michael P Caton

Edward Lunt

Keith A Stuttle

David J Lythgoe

Peter J Warne

Libert C Saunders

Robert K Chambers

Ian McClenaghan

Peter Lowden

Duncan C McDougall

David J Hambling

David W Gilmour

Adnan H Al-Shaar

Diane M Kelsey

Ethene derivatives

Tertiary alcohols of the formula: ##STR1## wherein Y.sup.1 represents a carbonyl or hydroxymethylene group, and either

Tertiary alcohols

8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.

Azapurinones

The invention provides certain novel 8-azapurin-6-one derivatives substituted in the 2-position by a substituted phenyl group, preferably carrying an alkoxy in the 2-position, which possess valuable pharmacological properties especially in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.

8-Azapurin-6-ones substituted in the 2-position by an unsubstituted or substituted phenyl or naphthyl group, or by an alkenyl or alkynyl group, a cycloalkyl group, an alkyl group contaning 2 to 10 carbon atoms, or an alkyl group containing 1 to 10 carbon atoms carrying one or more substitutents selected from halogen atoms and hydroxy, cycloalkyl, alkoxy, phenyl and substituted phenyl groups, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful, for example, in the treatment of allergic bronchial asthma.

Pharmaceutical compositions comprising azapurinones useful in treating

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Croydon, United Kingdom

Barbara Joyce Broughton