Alza Corporation

Durect Corporation

Barbara F Laidlaw

Atul D Ayer

Padmaja Shivanand

Zahedeh Hatamkhany

Felix T Theeuwes

Andrew I Poutiatine

Edward M Gillis

James E Brown

James A Filice

Randolph Mellus Johnson

John Culwell

John S Dinka

Dana Litmanovitz

Peter Wickman

Su-Il Yum

The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners

A therapeutic composition, a dosage form and a method are disclosed for administering phenytoin indicated for the management of epilepsy.

Phenytoin therapy

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San Jose, CA, United States of America

Barbara F Laidlaw