Claremont Biosolutions LLC

Keck Graduate Institute

Barbara Erwin

Bruce D Irvine

Robert Doebler

Ryan P Talbot

Anna Hickerson

James D Sterling

Ali Nadim

Robert W Doebler, Ii

Denice Woyski

Angelika Niemz

Angelika Brigitte Niemz

Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.

System, apparatus and method for material preparation and/or handling

Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Heating may be used. Lysing may be performed in a flow through apparatus.

Capture and elution of bio-analytes via beads that are used to disrupt specimens

Growing community of inventors

Ontario, CA, United States of America

Barbara Erwin