Hoechst Roussel Pharmaceuticals

Hoechst Marion Roussel

Barbara E Kurys

Edward J Glamkowski

David M Fink

Yulin Chiang

Gregory M Shutske

John D Tomer, Iv

Brian S Freed

Grover C Helsley

Gregory H Merriman

Russell R Hamer

Novel N-(pyridinylamino)isoindolines and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the N-(pyridinylamino)isoindolines and related compounds, the intermediates or compositions thereof are disclosed.

N-(pyridinylamino) isoindolines and related compounds

Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.

Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles

Pyridiniminyl-1,2-benzisothiazoles

This invention relates to 4- and 6-carbamates related to physostigmine of the formula ##STR1## where R.sub.1 is alkyl, cycloalkyl, bicycloalkyl, aryl or arylloweralkyl; R.sub.2 is hydrogen or alkyl or the group --NR.sub.1 R.sub.2 taken together forms a monocyclic or bicyclic ring of 5 to 12 carbons; m is 0, 1, or 2; each X is independently hydrogen, halogen, loweralkyl, nitro or amino; and the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. This invention also relates to novel intermediates useful in the preparation of the 4- and 6-carbamates. The compounds of this invention display utility for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.

4- and 6-carbamates related to physostigmine and intermediates for the

4-and 6-carbamates related to physostigmine and intermediates for the

This invention relates to compounds of the formula ##STR1## where X is --0--, --S--or --NH--;

8-azabicyclo[3.2.1]octane methanone and corresponding oximes

This invention relates to compounds of the formula ##STR1## where X is --O--, --S-- or --NH--;

Heteroaryl-8-azabicyclo[3,2,1]octanes as antipsychotic agents,

This invention relates to 4- and 6-carbamates related to physostigmine of the formula ##STR1## where R.sub.1 is alkyl, cycloalkyl, bicycloalkyl, aryl or arylloweralkyl; R.sub.2 is hydrogen or alkyl or the group --NR.sub.1 R.sub.2 taken together forms a monocyclic or bicyclic ring of 5 to 12 carbons; m is 0,1, or 2; each X is independently hydrogen, halogen, loweralkyl, nitro or amino; and the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. This invention also relates to novel intermediates useful in the preparation of the 4- and 6-carbamates. The compounds of this invention display utility for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.

Heteroaryl-8-azabicyclo[3.2.1]octanes as antipsychotic agents,

Novel benzo[b]pyrrolo[3,2,1-jk]benzodiazepines, intermediates and processes for the preparation thereof, and methods for alleviating pain utilizing the compounds or compositions thereof are disclosed.

Benzo(b)pyrrolobenzodiazepines

There are disclosed various derivatives of eseroline and related compounds of the formula below ##STR1## where R,R.sub.1, X,Z and m are as defined in the specification, which compounds being useful for enhancing cholinergic function, as antidepressant agents and as analgesic agents.

Growing community of inventors

Elmwood Park, NJ, United States of America

Barbara E Kurys