Georgia Tech Research Corporation

The University of Texas System

Children's Healthcare of Atlanta, Inc.

Osteobiologics, Inc.

Usbiomaterials Corporation

Barbara Dale Boyan

Zvi Schwartz

Robert Guldberg

Stephen J Kennedy

Christopher Douglas Hermann

Niren Murthy

Kyriacos A Athanasiou

David N Ku

Xinghai Ning

James D Heckman

Tamim Diab

David Scott Wilson

Andres Jose Garcia

Simon Van Dijk

David M Collard

Allan G Coombes

Timothy Petrie

David D Dean

Ramsey Christian Kinney

Abigail M Wojtowicz

Jenny E Raynor

Catherine D Reyes

Kenneth Henry Sandhage

David C Greenspan

Christopher S D Lee

Kristine M Kieswetter

Chandra Mauli Agrawal

Neil C Leatherbury

Gabriele G Niederauer

Lynda F Bonewald

Jonathan Vernon

Rolando A Gittens Ibacache

Shirae Kerisha Leslie

Ramsey C Kinney

Robert E Guldberg

Christopher SD Lee

Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.

Polymer hydrogels for in vivo applications and methods for using and preparing same

Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.

Protein delivery from stem cell microcarriers

The present invention provides implant devices comprising nanoscale structures on the surface thereof and methods of manufacturing such implant devices. In some embodiments, methods of manufacturing an implant device comprise exposing a surface of the implant device to an oxidative hydrothermal environment for a duration sufficient to generate nanoscale structures on the exposed surface(s) of the implant device.

Surface modification of implant devices

The invention is directed toward methods for assisting in interpreting medical images, especially useful for segmenting images produced by computed tomography or micro-computed tomography. In one embodiment, the invention is directed to method comprising initially identifying the images of the bones from a medical image, estimating a preliminary boundary of the bones, and subsequently segmenting the bones using a snake algorithm initialized by the preliminary boundary of the bones. The results can then be used to establish morphometric measurements from the medical images based on the segmented bone boundaries. In one embodiment of the present invention, the snake algorithm used is a continuous parametric Fourier series representation to fit and optimize the preliminary boundary of the bones to a more accurate representation of the segmented bone boundary from the data included in the image.

Cranial suture snake algorithm

Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.

Hydrogel implant with superficial pores

Articular joint implant

Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an &#x3b1;&#x3b2;or &#x3b1;&#x3b2;integrin-specific ligand are provided. The substrates and devices coated with an &#x3b1;&#x3b2;or &#x3b1;&#x3b2;integrin-specific ligand are shown to have greater tissue formation on the surface relative to controls, in particular greater bone formation.

Biomolecular coating for implants

Method of making load bearing hydrogel implants

Compositions and methods for producing encapsulated cells having an average diameter of less than about 200 &#x3bc;m are provided. Methods for using the disclosed encapsulated cells are also provided.

Microencapsulation of cells in hydrogels using electrostatic potentials

Method of treating joints with hydrogel implants

Surface directed cellular attachment

Load bearing biocompatible device

Growing community of inventors

Richmond, VA, United States of America

Barbara Dale Boyan