Beth Israel Deaconess Medical Center, Inc.

Harvard College

The Salk Institute for Biological Studies

Barbara B Kahn

Qin Yang

Alan Saghatelian

Tim Graham

Odile Peroni

Mark A Herman

Edwin Homan

Ismail Syed

Mark M Yore

Pedro M M Moraes Vieira

Daniel Kraus

Donald E Kahn

Mark M York

Pedro MM Moraes Vieira

The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders&#x2014;including diabetes-related disorders, Metabolic Syndrome, polycyctic ovarian syndrome, cancer, and inflammatory disorders&#x2014;using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

Lipids that increase insulin sensitivity and methods of using the same

Provided herein are methods for treating type 1 diabetes and its sequelae (e.g., cardiovascular, renal or neurologic diseases for which type 1 diabetes is a risk factor) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a fatty acid ester of a hydroxy fatty acid (FAHFA), or a pharmaceutically acceptable salt thereof.

Fatty acid esters of hydroxy fatty acids (FAHFAs) for use in the treatment of type 1 diabetes

The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders&#x2014;including diabetes-related disorders, Metabolic Syndrome, polycystic ovarian syndrome, cancer, and inflammatory disorders&#x2014;using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

The present invention, in various embodiments, relates to methods of inhibiting NNMT production or activity in a cell, and methods of treating or preventing obesity or a related metabolic condition in a subject in need thereof, comprising administering a nicotinamide N-methyltransferase (NNMT) antagonist. The invention further provides methods of identifying NNMT antagonists useful for treating obesity and related metabolic disorders.

Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT)

Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity.

RBP4 in insulin sensitivity/resistance, diabetes, and obesity

Sound shield

Growing community of inventors

Cambridge, MA, United States of America

Barbara B Kahn