Tissue Adhesive Technologies, Inc.

Mcdonnell Douglas Corporation

Conversion Energy Enterprises Inc.

Other

Montefiore Medical Center

Barbara Ann Soltz

Robert Soltz

Dale P DeVore

Braden P DeVore

Michael A Soltz

Charles R Chubb

Richard G Podgornik

Dale F Waldo

James D Cook

Thomas M Pallett

John M Haake

Victor H Nettle

Roy S Chuck

Michael Andrew Soltz

Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.

Methods and devices for crosslinking of corneal collagen and for treatment of disorders of the eye

Disclosed herein are compositions comprising gelatin, collagen, and a chromophore that produces a reactive oxygen species upon exposure to electromagnetic radiation. These compositions have also been found to be strong tissue adhesives that crosslinks the composition and tissue and are effective in closing and sealing wounds, fixation of grafts/implants and anastomoses.

Light activated composite tissue adhesives

A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.

Consistent with the present invention, a tube is provided that contains both a sensing and a laser delivery fiber to the target area. The length of the tube can be varied to any desired length. The end portion of the tube includes a second piece, which is a cap having two through holes or passages. These holes can be formed by standard machining or micromaching methods. The first hole can accommodate the sensing fiber, while the second hole contains the laser delivery fiber. The first and second holes extend in first and second directions, respectively, and form an angle therebetween such that the sensor fiber viewing area is within the radiation area created by the laser delivery fiber. Accordingly, the sensor fiber receives energy emitted from a central portion of the radiation area so that the temperature of the exposed tissue can be accurately determined.

Dual fiber-optic surgical apparatus

Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.

Composite tissue adhesive

Light energized tissue adhesive

Method for making a light energized tissue adhesive

Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 80 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films which are used to encapsulate structural components such as a cojoinal network or mesh. The resultant patch which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space and are reinforced by the embedded cojoinal network or mesh.

Light energized tissue adhesive conformal patch

A hand held laser apparatus containing a semiconductor laser diode switchably connected to a power supply. The output of the laser diode is focused and collimated by a pair of lens. Circuitry is provided to allow for either continuous wave or pulsed modes of operation as well as the capability of varying the pulsewidth of the laser. A guide laser or a light emitting diode is provided to guide the operator. The power level of the guide laser is limited so that it transfers minimal power to the workpiece but provides a visible line of laser light along which the output of the semiconductor laser diode will travel. A photodetector may be positioned between the laser diode and the lenses. Additionally, the amount of current delivered to the laser in continuous wave mode of operation or the pulse width and duty cycle of a pulse may be measured and displayed. Embodiments are provided incorporating a plurality of laser diodes to allow continued operation upon failure of a diode, increased power with the simultaneous use of the multiple diodes, or either alternate wavelength selection or wavelength mixing. Alternative embodiments operate at a predetermined voltage level. These embodiments may utilize a set of batteries such that the entire batteries and control circuitry may be contained either within a portable package or the hand held laser apparatus itself. Such alternative embodiments may be made so as to be disposable upon the discharge of their batteries or the exhaustion of the laser.

Hand held laser apparatus

A laser diode apparatus for initiating explosives or other pyrotechnic devices that has capability of checking both the laser diode operation and the optical fiber continuity between the laser diode source and the explosives required to be detonated. Power isolation circuits are provided to control the flow of current to the laser diode, also isolation filters are used to allow only the command signals to initiate the firing circuits employed.

Growing community of inventors

Spring Valley, NY, United States of America

Barbara Ann Soltz