Selective Genetics, Inc.

Other

The Whittier Institute for Diabetes & Endocrinology

Tissue Repair Company

Prizm Pharmaceuticals, Inc.

Barbara A Sosnowski

J Andrew Baird

Lois Ann Chandler

David T Curiel

Andrew J Baird

Glenn Pierce

Douglas A Lappi

Glenn Francis Pierce

Joanne T Douglas

Isabel Barthelemy

Buck E Rogers

Disclosed are methods for use in transferring nucleic acids into cells at a wound site associated with a fluid space. These gene transfer protocols are suitable for use in transferring various nucleic acids into cartilage, cardiac muscle, and other tissues, and have many uses including treating diseases such as arthritis and ischemic heart disease, and promoting wound healing. The invention further disclosed pharmaceutical compositions that may be used in the practice of the invention to transfer the nucleic acid of interest. Such compositions include any multi-partitioned biocompatible matrix in combination with multiple nucleic acids of interest.

Traversal of nucleic acid molecules through a fluid space and expression in repair cells

Preparations of conjugates of a receptor-binding internalized ligand and a cytocide-encoding agent and compositions containing such preparations are provided. The conjugates contain a polypeptide that is reactive with an FGF receptor, such as bFGF, or another heparin-binding growth factor, cytokine, or growth factor coupled to a nucleic acid binding domain. One or more linkers may be used in the conjugation. The linker is selected to increase the specificity, toxicity, solubility, serum stability, or intracellular availability, and promote nucleic acid condensation of the targeted moiety. The conjugates are complexed with a cytocide-encoding agent, such as DNA encoding saporin. Conjugates of a receptor-binding internalized ligand to a nucleic acid molecule are also provided.

Compositions containing nucleic acids and ligands for therapeutic treatment

The present invention relates to gene therapy. In particular, therapeutic agents, therapeutic gene products, and compositions are disclosed. Various systems and methods useful in targeting and delivering non-native nucleotide sequences to specific cells are disclosed, wherein virus-antibody-ligand conjugates are used to facilitate targeting and delivery.

Viral vectors with modified tropism

Compositions containing nucleic acids and ligands for therapeutic

Recombinant production of saporin-containing proteins

Growing community of inventors

Coronado, CA, United States of America

Barbara A Sosnowski