Picarro, Inc.

Codex Beauty Corporation

Blueleaf, Inc.

Informed Diagnostics, Inc.

Informal Diagnostics, Inc

Barbara A Paldus

Bruce A Richman

Alexandre Katchanov

Marc Cornell

Jinchun Xie

Eric R Crosson

Alexander Katchanov

Robert Lodenkamper

Chris W Rella

Grzegorz Pakulski

Daniele Romanini

Arnaud Garnache

Frederic Stoeckel

Sze Meng Tan

Serguei Koulikov

Alexander Kachanov

Charles C Harb

Marc Levenson

Guido Knippels

Christopher Rella

Jorge Iván Sanhueza Sepúlveda

David M Adams

Richard Neil Zare

Bernard G Fidric

Robert Provencal

Gerard Meijer

Tracey Ryan

The present disclosure is directed to a composition for managing exaggerated sebum production in oily-prone skin, the composition containing: (1) a mixture of at least: (a) from about 0.02 to about 1% by weight of an ingredient capable of activating cannabinoid type-2 receptors ('CB'); (b) from about 0.1 to about 3% by weight of a blend ofandalgae extracts; (c) from about 0.1 to about 4% by weight of an extract of; and (d) from about 0.01 to about 0.05% by weight of an extract of Tulsi, wherein all weights are based on total weight of the composition; (2) optionally, an emulsifier; and (3) a dermatologically acceptable carrier, wherein the composition has a pH ranging from about 4.5 to about 5.5.

Skin care compositions and methods for regulating sebum production

Compositions intended for application onto human skin damaged by oxidative stress can include (1) a mixture of at least: (a) a leaf extract of; (b) a leaf extract of; (c) a leaf extract of; (d) optionally, a bark/seed extract of; (e) optionally, a blend of, andextracts; and (f) at least one humectant; (2) an emulsifier; and (3) a dermatologically acceptable carrier, wherein (a)-(f) are employed in amounts sufficient to synergistically neutralize existing free radicals present in the skin, while proactively priming the skin by repairing and/or protecting itswithout unduly impairing the's acid mantle, and wherein the composition is natural, free of a skin-sensitizing amount of an essential oil, and has a pH ranging from about 4.5 to about 5.5.

Natural skin care compositions and methods for treating oxidative stress and restoring skin health

The present disclosure is directed to a composition intended for application onto human skin suffering from oxidative stress, the composition comprising: (1) a mixture of at least: (a) a leaf extract of; (b) a leaf extract of; (c) a leaf extract of; (d) optionally, a bark/seed extract of; (e) optionally, a blend of, andextracts; and (f) at least one humectant; (2) an emulsifier; (3) a dermatologically acceptable carrier; and (4) a film former, wherein (a)-(f) are employed in amounts sufficient to neutralize existing free radicals present in the skin, while proactively priming the skin in order to enhance its ability to protect itself against free radical aggression caused by exposome-induced oxidative stress and dry skin-inducing water loss, wherein the composition is natural and free of a skin sensitizing-effective amount of an essential oil.

Compositions intended for application onto human hair, skin, and/or nails can include an antimicrobial effective amount of a preservative system containing: (a) from about 2 to about 5% by weight of aferment; (b) from about 2 to about 5% by weight of awith or withoutferment; (c) from about 0.1 to about 0.5% by weight of at least one co-preservative ingredient chosen from salicylic acid and a salt of a weak acid; and (d) from about 1 to about 10% by weight of a petroleum-free propanediol, all weights based on the total weight of the composition, wherein the composition has a pH ranging from about 4.8 to about 5.5.

Preservative systems and compositions and methods incorporating same

The present disclosure is directed to a composition and method of enhancing skin health and appearance, as well as treating compromised skin, by applying onto the skin a composition containing a moisturizing/hydrating-effective amount of a mixture of at least: (a) an oil infusion ofextract; (b) an oil infusion ofextract; (c) an oil infusion ofextract; (d) an aqueous infusion ofextract; and (e) an aqueous infusion of at least oneextract chosen fromextract andextract; and an emulsifying-effective amount of a dermatologically-acceptable emulsifier, wherein the composition is natural and free of a skin sensitizing-effective amount of an essential oil.

Compositions and methods for treating skin

A gaseous target analyte present as a minor constituent in an admixture with at least one other gaseous species can be detected using a cavity enhanced optical spectrometer by a process comprising the steps of:

Method for detecting a gaseous analyte present as a minor constituent in an admixture

Improved cavity ring down spectroscopy is provided by binning decay time vs. wavelength data into wavelength bins defined by discontinuities in a wavelength monitor signal. Average decay times and average wavelengths are computed for each bin. The optical loss of a target analyte at the average wavelengths is determined from the corresponding average decay times.

Method for the precise measurement of the wavelength of light

A cavity enhanced optical detector comprising: i) a source of continuous wave laser light; ii) a high finesse resonant cavity comprising at least three spaced apart, high-reflectivity mirrors positioned to receive light from the laser light source; iii) at least one photo-detector for measuring the extinction coefficient of an analyte that is positioned in the resonant cavity; and iv) one or more additional photo-detectors for measuring the intensity of fluorescence emission and/or Raman scattering from the analyte.

Cavity enhanced optical detector

An apparatus for cavity enhanced optical detection having an improved flow cell is provided. Sensitivity of the cavity resonance condition to changes in refractive index of an analyte flowing through the flow cell is reduced. More specifically, the round trip optical path defined by the resonant cavity intersects a curved cavity input mirror at a point. This point has a location on the input mirror that is substantially independent of the refractive index of the analyte. In this manner, changes in sample refractive index do not lead to misalignment of the resonant optical cavity.

Flow cell for optical detection having reduced sensitivity to refractive index variation

A cavity ring-down spectrometer includes:

Wavelength control for cavity ringdown spectrometer

A tunable laser and laser tuning method, based on the interaction of a spectrally dependent beam distortion and a spatial filter within a laser cavity. One embodiment of this laser is an external cavity semiconductor laser in which broad tunability is obtained by the insertion of an acousto-optic tunable filter (AOTF) into the laser cavity such that the intra-cavity laser beam passes through the AOTF in zeroth order.

Laser tuning by spectrally dependent spatial filtering

A tunable laser and laser tuning method based on the use of a tunable etalon in reflection as a mirror within a laser cavity and forming an end reflective surface thereof. The laser emission wavelength is not necessarily at a wavelength of peak etalon reflectivity. A preferred embodiment makes use of a microelectromechanical etalon to tune an external cavity semiconductor.

Laser with reflective etalon tuning element

A laser tuning mechanism which embodies 'spectrally dependent spatial filtering' (SDSF) and contemplates two key elements of the tuning mechanism. The first element of the SDSF tuning mechanism is a spectrally dependent beam distortion (i.e. alteration of the amplitude and/or phase profile of the beam) provided by an SDSF tuning element in a laser cavity. The second element of the SDSF tuning mechanism is an intracavity spatial filter which makes the round trip cavity loss a sensitive function of both beam distortion and cavity alignment. Such a laser can be aligned so that a specific beam distortion, which is provided by the SDSF tuning element at a tunable wavelength, is required to obtain minimum round trip cavity loss, thereby providing tunable laser emission. A preferred embodiment of the SDSF tuning mechanism is an external cavity semiconductor laser having a zeroth order acousto-optic tuning element.

Laser Tuning by spectrally dependent spatial filtering

A tunable laser and laser tuning method based on the use of a tunable etalon in reflection as a mirror within a laser cavity. The laser emission wavelength is not necessarily at a wavelength of peak etalon reflectivity. A preferred embodiment makes use of a microelectromechanical etalon to tune an external cavity semiconductor laser.

According to the present invention, laser performance is improved by appropriately matching the spectral periods of various etalons within the laser cavity. A first embodiment of the invention is a discretely tunable external cavity semiconductor laser where a grid fixing etalon is present in the laser cavity, the grid fixing etalon free spectral range (FSR) is a whole number multiple of the laser cavity FSR, and the grid fixing etalon FSR is a whole number multiple of the chip etalon FSR. A second embodiment of the invention is a fixed wavelength external cavity semiconductor laser where the chip etalon FSR is a whole number multiple of the laser cavity FSR, and a mode suppressing etalon is inserted into the laser cavity such that the mode suppressing etalon FSR is a whole number multiple of the chip etalon FSR. A third embodiment of the invention is a tunable external cavity semiconductor laser where the chip etalon FSR is a whole number multiple of the laser cavity FSR. A fourth embodiment of the invention is a fixed wavelength external cavity semiconductor laser where the chip etalon FSR is a whole number multiple of the laser cavity FSR.

Growing community of inventors

Portola Valley, CA, United States of America

Barbara A Paldus