Merck + Co., Inc.

Barbara A Jackey

Michel M Chartrain

Brian Heimbuch

Thomas R Verhoeven

Paul J Reider

Colleen S Taylor

Chris H Senanayake

F Edward Roberts

Neal C Connors

Randolph L Greasham

Francis P Gailliot

Roger C Olewinski, Jr

Chanyong Lee

Barry C Buckland

A method for preparing (1S)-amino-(2R)-indandiol substantially free of its stereoisomers is presented. The method comprises culturing indene with Rhodococcus sp. ATCC 55805, recovering the indandiol and subjecting the indandiol to chiral specific crystallization, treatment with strong acid and reverse ion pair extraction.

Conversion of indene to (1S)-amino-(2R)-indanol free of any steroisomer

A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp., followed by various chemical step(s), e.g., chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.

Conversion of indene to (1S)-amino-(2R)-indanol free of any

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Bloomfield, NJ, United States of America

Barbara A Jackey