University of Texas System

Baran D Sumer

Jinming Gao

Yang Li

Yiguang Wang

Xinpeng Ma

Gang Huang

Tian Zhao

Kejin Zhou

Tongyi Huang

Qiang Feng

Xu Wang

Houliang Tang

Wei Li

Jonathan Wilhelm

The present disclosure relates to degradable polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and have backbones which are capable of undergoing degradation in vivo. In some aspects, the disclosure also provides methods of using these degradable polymers for the delivery of a drug.

Biodegradable ultra-pH sensitive polymers

Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.

PH responsive block copolymer compositions and micelles that inhibit MCT 1 and related proteins

The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

Library of pH responsive polymers and nanoprobes thereof

The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

Multicolored pH-activatable fluorescence nanoplatform

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Dallas, TX, United States of America

Baran D Sumer