Sarepta Therapeutics, Inc.

Baozhong Cai

Mitchell Martini

Ross Shimabuku

Katie Thomas

Richard Keith Bestwick

Diane Elizabeth Frank

Patrick L Iversen

Frederick Joseph Schnell

Jason Gatlin

Provided herein are processes for preparing an oligomer (e.g., a morpholino oligomer). The synthetic processes described herein may be advantageous to scaling up oligomer synthesis while maintaining overall yield and purity of a synthesized oligomer.

Phosphorodiamidate morpholino oligomers

Provided herein are processes for preparing an oligomer (e.g., a morpholino oligomer). The synthetic processes described herein may be advantageous to scaling up oligomersynthesis while maintaining overall yield and purity of a synthesized oligomer.

Processes for preparing phosphorodiamidate morpholino oligomers

A modified antisense oligonucleotide of about 10 to about 40 nucleobases is disclosed. The oligonucleotide comprises a targeting sequence having a region complementary to at least one string of three or more identical contiguous nucleobases in a target sequence, wherein the target sequence comprises at least one additional nucleobase compared to the region of the targeting sequence and the at least one additional nucleobase has no complementary nucleobase in the region of the targeting sequence, and wherein the targeting region complementary to the at least one string of three or more identical contiguous nucleobases is internal to the targeting sequence.

Antisense oligomer compounds

Processes for preparing oligomers

Growing community of inventors

Cambridge, MA, United States of America

Baozhong Cai