Shenyang Research Institute of Chemical Industry Co., Ltd.

Sinochem Corporation

Shenyang Sinochem Agrochemicals R&d Co., Ltd.

Baoshan Chai

Changling Liu

Zhinian Li

Aiying Guan

Hong Zhang

Junfeng Wang

Huichao Li

Bin Wang

Xufeng Sun

Jie Lan

Qin Sun

Jichun Yang

Lizeng Wang

Shaowu Liu

Zhonggang Shan

Lanhui Ren

Cong Feng

Minna Zhu

Yongwu Peng

Miao Li

Yuquan Song

Jinbo Zhang

Yanmei Luo

Guang Huang

Xiuhui Chang

Baoxiang Sun

Jizhong Zhou

Xiaomin He

Jiao Wu

Shicun Ma

Guangxin Liu

Wanqiu Wang

Weijing Ren

Yinping Zhou

Wei Chen

Fan Yang

Xiaoping Yang

Jiayuan Jiao

Haihong Guang

Zhaojin Ran

The present invention relates to a vinylarene deriv. which modulates or inhibits the enzymic activity of indoleamine 2,3-dioxygenase 1 (IDO-1), and the use thereof, and further relates to a vinylarene deriv. and the use thereof. The vinylarene deriv. and its stereoisomer, cis- or trans-isomer, or tautomer thereof and pharmaceutically acceptable salt thereof, has an IDO-1 enzyme inhibitory activity, and is expected to provide brand new therapeutic methods and schemes for related diseases caused by IDO enzymes. 

Vinylarene derivative and application

Disclosed are applications of substituent benzyloxy group containing ether compounds represented by general formula I for preparing antitumor drugs.  The definition of the substituent groups in the formula I are provided in the specification. The compounds having general formula I have desirable antitumor activity, particularly, and have excellent activity against leukemia strain HL-60, lung cancer A549, H157, H460, H520, bladder cancer T24, J82, prostate cancer LNCap, PC-3, rectal cancer HCT8, HCT116, RkO and the like.

Applications of substituent benzyloxy group containing ether compounds for preparing antitumor drugs

Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY.  See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.

Substituted pyrimidine compound and uses thereof

The invention discloses a homopiperony lamine compound which has a structural general formula I as follows as shown in the specification:  The compound shown as the general formula I has broad-spectrum bactericidal and insecticidal activity in the field of agriculture. The compound shown as the general formula I has a good prevention effect on various germs such as cucumber downy mildew, wheat powdery mildew,, rice blast and cucumber gray mold, and particularly, still has the good prevention and control effect on the cucumber downy mildew, theand the wheat powdery mildew at a lower dosage. At the same time, a part of compound has better insecticidal activity, and can be used for preventing and controlling various insect pests such as diamondback moths,, armyworms andboisdu.

Substituted pyrimidines as pharmaceuticals and insecticides

The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I):  The groups are as defined as specification. The compound represented by formula (I) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer.

Substitute diphenylamine compounds use thereof as antitumor agents

The invention relates to substituted pyrimidine ammonia compounds. The structure of the compounds is represented as the general formula (I):  The groups are as defined as specification. The compound represented by formula (I) can be used in the prevention of plants diseases caused by a plurality of pathogenic bacteria such as oomycota, basidiomycota, ascomycota, and fungi imperfecti, and due to these compounds have good bioactivity, which make them have very good effects at very low doses, especially more effective to powdery mildew of wheat. Therefore, the present invention relates to the use of the compounds having general formula I as fungicides, both in agriculture and other fields.

Substituted pyrimidine ammonia compounds and uses thereof

Disclosed is a kind of E-type phenyl acrylic ester compound containing substituted anilino pyrimidine group, which is shown by general structure formula I, wherein each substituent is defined as that in the description. The compounds of general formula I show high insecticidal and acaricidal activities to adults and nymphs of harmful insects and mites in agricultural, civil and zoic technical fields, especially to, Tetranychidae, and the like. The said compounds show more excellent performance on inhibiting the incubation of eggs of harmful mites. The uses of the said compounds as insecticides and/or acaricides in agricultural and other fields also are disclosed.

[object Object]

Amide compounds, preparation methods and uses thereof. The structure of the compounds is represented as the general formula (I), in which the definitions of substituents are illuminated as description. The present amide compounds have broad spectrum activity of killing pests and are effective on lepidopteran pests including, sugarcane borer,fischer von reslerstamm, apple fruit borer,l.,etc., especially for. The present amide compounds can obtain good effect at very low dosage. At the same time, some compounds have good fungicidal activity which can be used to prevent rice blast,infestans, cucumber downy mildew or grey mold of vegetables.

Amide compounds, preparation methods and uses thereof

The invention relates to substituted pyrimidine ether compounds having general formula I:  The groups are as defined as specification. The compounds of formula I show high insecticidal activities for imagoes, larvae and nits of harmful acari and insects in the agricultural, civil and zoic fields, especially show excellent insecticidal activities for harmful acari such as. Good effects can be obtained at very low dose. The compounds also exhibit preferably fungicidal activity. Wherefore, the invention also comprises the uses of compounds of formula I as insecticides, acaricides and/or fungicides in agricultural and other fields.

Substituted pyrimidine ether compounds and use thereof

Growing community of inventors

Liaoning, China

Baoshan Chai